A. Sharma

The paper shows that Plasmodium ANKA parasites exhibit ECM-specific gene expression profiles that are activated only in susceptible hosts, indicating host influence on cerebral malaria outcomes.

This study identifies key parameters to optimize plant regeneration using developmental regulators in monocot and eudicot species.

This study analyzes temporal gene expression patterns of VEGF-A and VEGF-B in a murine SARS-CoV model, revealing dynamic changes and potential interactions with SARS-CoV-2 Spike protein.

The paper identifies three monoclonal antibodies that poorly neutralize the Omicron BA.1 variant, revealing structural and molecular features of antibody evasion.

This study maps two recessive resistance genes, bs5 and bs6, against bacterial spot in pepper, aiding marker-assisted breeding and resistance mechanism understanding.

The paper shows that fluid flow increases bacterial sensitivity to chemical stress by altering H2O2 gradients and transcriptional responses in Pseudomonas aeruginosa and Staphylococcus aureus.

This study identifies a selective loss of CD107a+ TIGIT+ memory HIV-1-specific CD8+ T cells in PLWH on long-term ART, which can be reversed by TIGIT blockade.

This study shows that ELMO1 and NOD2 interact to control intestinal inflammation and bacterial clearance, with their dysfunction linked to Crohn's disease.

This study shows that long-chain bacterial polyphosphates induce CXCL4 release from macrophages and synergize with C5a to cause lung injury.

This study examines the impact of wastewater treatment upgrades on the microbiome of an urban river system over seven years, finding that seasonality, not the upgrades, dominated microbial community dynamics.

This paper develops an in situ gel formulation of azithromycin with sulfobutylether-β-cyclodextrin to improve ocular delivery and antimicrobial efficacy for treating bacterial conjunctivitis.

This study evaluates VAR2CSA-based placental malaria vaccines in Aotus monkeys, finding limited cross-reactivity and functional activity similar to human trials.

This paper identifies and structurally analyzes an antibody that neutralizes SARS-CoV-2 BA.1 and BA.2 variants, revealing its unique epitope and mechanism of action.

This study investigates the evolutionary origins and loss of TCP genes, finding that the C6 gene arose through sequential domain gains and the C9 gene was lost in galliform birds.

This study designs mosaic RBD nanoparticles to elicit antibodies against conserved sarbecovirus epitopes, showing broader protection against SARS-CoV-2 variants and animal sarbecoviruses in animal models.

This paper develops a CRISPR-Cas base editing method to generate targeted loss-of-function mutants in Shigella flexneri with high efficacy and throughput.

This study identifies large haploblocks as key drivers of rapid local adaptation in Ambrosia artemisiifolia across different climates.

This study shows that human defensins HNP1 and RC-101 destabilize SARS-CoV-2 Spike protein and inhibit viral infection in cell culture.

The paper presents a dataset supporting labyrinthin as a pan-adenocarcinoma marker through topology, homology, and cell surface localization analyses.

This study identifies gene interactions related to cardiotoxicity and neurotoxicity in zebrafish using induced network modules analysis of existing databases.

This paper develops a multi-omics protocol to study early human neuronal differentiation, identifying transcriptional waves and providing tools for data exploration.

This paper shows that the synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates through various vaccination routes and dose regimens.

This study sequenced the mitogenome of Indian one-horned rhinos to assess genetic variation and evolutionary history, identifying three distinct genetic clades and proposing three Evolutionary Significant Units for conservation.

The paper shows that age-related grey matter demyelination and neurodegeneration in MS are linked to meningeal neutrophil accumulation in an animal model.

This study analyzes the POTE protein family to understand their structure, function, and adaptive divergence, identifying potential therapeutic applications in cancer.

This study identifies autophagy inhibitors as potential therapies for NF1 tumors by showing their effectiveness in Drosophila and human models.

The paper determines the tetrameric structure of the Tat receptor complex in bacterial membranes using single molecule photobleaching analysis.

The paper shows that SOCS1 deficiency leads to increased SOCS3 expression, which activates the p53-p21-NRF2 axis, reducing oxidative stress and HCC progression.

This study evaluates how different lighting conditions affect kratom plant growth and alkaloid synthesis, finding that shaded greenhouse conditions increase certain alkaloid concentrations and total leaf alkaloid yield.

The paper develops an analytical theory to explain domain registration and anti-registration in biological membranes by analyzing enthalpic and entropic contributions to interleaflet coupling.