H. Lv

Deep mutational scanning of influenza A virus NEP reveals pleiotropic mutations in its N-terminal domain

This study uses deep mutational scanning to analyze the functional impact of NEP mutations in influenza A virus, revealing pleiotropic effects on viral replication and host adaptation.

Differential antigenic imprinting effects between influenza H1N1 hemagglutinin and neuraminidase in a mouse model

This study examines how immune history affects antibody responses to influenza H1N1 hemagglutinin and neuraminidase in mice, finding that HA responses are more restricted by prior infection than NA responses.

Natural variation in neuraminidase activity influences the evolutionary potential of the seasonal H1N1 lineage hemagglutinin

This study shows that natural variation in neuraminidase activity affects the evolutionary potential of hemagglutinin in seasonal H1N1 influenza viruses.

HER2 Prognostic Significance and Therapeutic Implications in Gastric Cardia Adenocarcinoma: Insights from Multi-Omics Profiling

This study identifies HER2 as a prognostic marker in GCA and suggests anti-inflammatory and immune checkpoint inhibition as therapeutic strategies for HER2-negative patients.

An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies

This study curates a dataset of influenza HA antibodies and develops an explainable language model to predict antibody specificity, identifying and validating HA stem antibodies.

Targeting CD301+ macrophage inhibits endometrial fibrosis and improves pregnancy outcome

This study identifies CD301+ macrophages as drivers of endometrial fibrosis and infertility, showing their inhibition improves pregnancy outcomes in mice.

Widespread impact of immunoglobulin V gene allelic polymorphisms on antibody reactivity

This study shows that IGV allelic polymorphisms widely affect antibody reactivity by analyzing antibody-antigen structures and experimental data.

Lack of neutralizing antibodies against the current circulating influenza viruses during the Omicron outbreak in Hong Kong

The paper reports low neutralizing antibody levels against influenza A H1N1 and H3N2 viruses in adults during the Omicron outbreak, emphasizing the need for influenza vaccination.

Evaluation of antibody kinetics and durability in health subjects vaccinated with inactivated COVID-19 vaccine (CoronaVac): A cross-sectional and cohort study in Zhejiang, China

This study evaluates antibody kinetics and durability after CoronaVac vaccination in health subjects, finding waning antibody levels over time and improved responses with a booster dose.

Effects of protoscoleces excretory-secretory products of Echinococcus granulosus on hepatocyte growth, function, and glucose metabolism

This study investigates how excretory-secretory products from Echinococcus granulosus protoscoleces affect mouse hepatocyte growth, function, and glucose metabolism, finding inhibition of proliferation, promotion of apoptosis, and disruption of metabolic pathways.

Age-related seroprevalence trajectories of seasonal coronaviruses in children

This study examines age-related seroprevalence of four seasonal coronaviruses in children and postpartum women, showing waning passive immunity and resurgence of IgGs with age.

Spatiotemporal heterogeneity and the long-term impact of meteorological , environmental and socio-economic factors of scrub typhus in China from 2012 to 2018

This study analyzes the spatiotemporal patterns of scrub typhus in China from 2012 to 2018, identifying key meteorological, environmental, and socio-economic factors influencing its distribution.

Molecular analysis of a public cross-neutralizing antibody response to SARS-CoV-2

The paper identifies a public antibody response that cross-neutralizes all SARS-CoV-2 variants, including Omicron, by analyzing published data on germline gene combinations and molecular features.

Genomic insights into the adaptive and convergent evolution of Leuciscus waleckii inhabiting extremely alkaline environments

This study identifies genomic adaptations in Leuciscus waleckii to extreme alkaline environments through genome assembly and population analysis.

FoxP3-mediated blockage of ryanodine receptor 2 is the molecular basis for the contact-based suppression by regulatory T cells

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

Egg-adaptation pathway of human influenza H3N2 virus is contingent on natural evolution

The paper shows that natural mutations in human H3N2 HA influence the egg-adaptation pathway, affecting mutation emergence during vaccine production.

Homologous and heterologous serological response to the N-terminal domain of SARS-CoV-2

The paper examines the serological response to the N-terminal domain (NTD) of SARS-CoV-2, showing it is less cross-reactive with SARS-CoV and less effective as an immunogen compared to the RBD.

Evidence of antigenic imprinting in sequential Sarbecovirus immunization

This study shows that prior exposure to one Sarbecovirus strain biases antibody response to a subsequent, antigenically distinct strain, suggesting antigenic imprinting affects immunity to SARS-CoV-2.

Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections

This study examines cross-reactive antibody responses between SARS-CoV-2 and SARS-CoV, finding common binding but rare neutralization, suggesting non-neutralizing antibodies target conserved epitopes.

A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV

Structural study of a cross-reactive SARS antibody reveals a conserved epitope on the SARS-CoV-2 receptor-binding domain.