R. Sheng

Golgi-associated retrograde protein (GARP) complex recruits retromer to trans-Golgi network for FgKex2 and FgSnc1 recycling, necessary for development and pathogenicity of Fusarium graminearum

This study identifies the GARP complex as a mediator that recruits retromer to the trans-Golgi network, facilitating the recycling of FgKex2 and FgSnc1, which is essential for growth, development, and pathogenicity of Fusarium graminearum.

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

This study identifies convergent therapeutic targets for chemoresistance in cancer using CRISPR screens across multiple drug conditions and cancer models.

USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase transition potential

This study identifies USP10 as a novel regulator of β-catenin through dual mechanisms involving deubiquitination and phase separation, with implications for cancer treatment.

Implantation of engineered adipocytes that outcompete tumors for resources suppresses cancer progression

The paper shows engineered adipocytes can suppress cancer progression by competing for nutrients in multiple cancer types.

Multiomics reveal that silk fibroin and sericin differentially potentiate the paracrine functions of mesenchymal stem cells and enhance tissue regeneration

This study uses multiomics to show that silk fibroin and sericin enhance mesenchymal stem cell paracrine activity and tissue regeneration through distinct pathways.

SIRT1 ameliorates premature senescence-induced defenestration in hepatic sinusoidal endothelial cell

This study shows that SIRT1 reduces premature senescence-induced defenestration in hepatic sinusoidal endothelial cells by deacetylating p53 and mitigating oxidative damage.