J. Guo

The paper uses RNA-sequencing to analyze the transcriptome of canine XLMTM muscle after rAAV8-cMTM1 gene transfer, showing dose-dependent normalization of gene expression and identifying new disease-related transcripts.

This study compares energy expenditure measurements using doubly labeled water (DLW) and respiratory chambers during very low-carbohydrate diets, finding that DLW overestimates energy expenditure when not adjusted for respiratory quotient changes.

This study compares objective energy intake changes calculated via a mathematical model with self-reported 24-hour recalls during low-carbohydrate and low-fat diets, finding greater early calorie restriction with low-carbohydrate diets but no long-term differences.

This study identifies two FDA-approved drugs, lacidipine and phenothrin, as Lassa virus entry inhibitors through high-throughput screening and mechanistic analysis.

This study identifies a bacterial community YFMCD4 that effectively removes microcystin-LR from water, with degradation rates influenced by temperature, pH, and concentration.

The paper analyzes ascitic microbiota composition in cirrhotic patients and finds two microbial clusters associated with different clinical outcomes, particularly higher short-term mortality in one cluster.

The paper profiles sgRNA activity in E. coli to improve CRISPR/Cas9 efficiency and identifies limitations of existing prediction models.

This study shows that triclosan exposure induces antibiotic resistance in E. coli through genetic mutations and gene expression changes.

This paper develops a CRISPRi library for high-throughput functional genomics in E. coli, identifies sgRNA design rules, and validates gene-phenotype associations with high specificity.

This paper develops an inducible CRISPR-ON system to controllably activate genes in human pluripotent stem cells, demonstrating its ability to regulate NANOG expression and enhance cell survival and integration with mouse blastocysts.