J. H. Lee

The paper introduces a method to selectively propagate specific cells using hydrogel micropatterning based on imaging features.

This paper introduces a lossless immunocytochemistry method using photo-polymerized hydrogel thin-films, which preserves cell samples with fewer than 10,000 cells.

This study shows PD-L1 CAR-engineered NK cells kill cancer cells and inhibit tumor growth by targeting PD-L1, reducing myeloid cells in both preclinical models and patient blood.

The paper develops a CRISPR-based platform combining deaminase and scRNA-seq to introduce and assess substitution mutations, enabling high-throughput analysis of mutation-associated transcriptional effects.

This study shows that SRP-induced compaction of SR and GTPase movements are essential for efficient cotranslational protein translocation at the ER, with implications for disease.

The paper shows that DNA damage induces heterogeneous transcriptome responses in cancer cells, with distinct transcriptional programs dictating cell fate outcomes such as checkpoint, apoptosis, or chemoresistance.

This study shows that IL-1β disrupts β-cell circadian clocks by impairing Bmal1 expression and alters its DNA-binding patterns, linking circadian disruption to β-cell failure in diabetes.

The paper introduces an injectable neural stimulation electrode made from a polymer/metal composite that conforms to neural structures and performs similarly to traditional electrodes in rats and swine.

This paper identifies PNGM-1, a dual-activity enzyme with metallo-β-lactamase and tRNase Z functions, and shows it evolved from tRNase Z, providing insights into the origin of subclass B3 metallo-β-lactamases.

This study shows that high serum neutralizing antibody titers from Env protein vaccination protect rhesus macaques from Tier 2 SHIV challenge, with ~1:500 ID50 titers providing over 90% protection.

This study shows that p53 loss decreases single-cell motility and invasion in 2-D and 3-D assays, but promotes collective cellular migration in spheroids.

This study identifies lysine residues critical for BMP2 degradation and shows genetic modifications can enhance its stability and extracellular secretion.

The paper reports multiple pepper genomes and finds that retroduplication via LTR-retrotransposons drives expansion of disease resistance genes in plants.

This study investigates whether disrupted cholinergic modulation in the primary auditory cortex contributes to abnormal gamma rhythms and auditory hallucinations in schizophrenia.