X. Pang

Deciphering the Transcription Factor Landscape in Neuroendocrine Prostate Cancer Progression: A Novel Approach to Understand NE Transdifferentiation

This study identifies lineage-specific transcription factor profiles in prostate cancer progression, revealing dynamic shifts during NE transdifferentiation and proposing a three-phase model.

Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms

Structural elucidation of how ARF small GTPases induce membrane tubulation for vesicle fission

The paper determines the structure of ARF6 protein lattice on tubulated membranes, revealing its role in vesicle fission and how GAP proteins interact with it.

Impact of Ghost Introgression on Coalescent-based Species Tree Inference and Estimation of Divergence Time

This study examines how ghost introgression affects species tree inference and divergence time estimation using mathematical analysis and simulations.

Effects of dual deletion of glnR and mtrA on expression of nitrogen metabolism genes in Streptomyces venezuelae

This study examines how the dual deletion of glnR and mtrA affects nitrogen metabolism gene expression in Streptomyces venezuelae, revealing GlnR's decisive role and MtrA's GlnR-dependent regulation.

The Oncoprotein BCL6 Enables Cancer Cells to Evade Genotoxic Stress

This study shows that BCL6 helps cancer cells survive genotoxic stress by repressing PTEN and enhancing interferon responses, suggesting BCL6 inhibition could improve cancer treatment.

Cryo-EM structures reveal interactions of S-OPA1 with membrane and changes upon nucleotide binding

The paper uses cryo-EM to study SOPA1's structure and conformational changes upon GTP binding, revealing its unique mechanism in mitochondrial membrane fusion.

New interfaces on MiD51 for Drp1 recruitment and regulation

This study identifies two regions on MiD51 that bind Drp1 and shows that MiD51 dimerization via a disulfide bond is required for Drp1 recruitment, revealing a multi-faceted regulatory mechanism for mitochondrial fission.