L. Hou

Down regulation of Engase in Caenorhabditis elegans may improve its stresses adaptivity

This study shows that downregulating CeEngase in C. elegans enhances its adaptability to heat and osmotic stress.

Molecular basis of Ad5-nCoV Vaccine-Induced Immunogenicity

This study investigates the molecular basis of Ad5-nCoV vaccine-induced immunogenicity by analyzing the structure and properties of the spike antigens it induces.

Co-occurrence of Direct and Indirect Extracellular Electron Transfer Mechanisms during Electroactive Respiration in a Dissimilatory Sulfate Reducing Bacterium

This study investigates the extracellular electron transfer (EET) mechanisms in Desulfovibrio vulgaris Hildenborough, revealing both direct and indirect EET pathways and their role in microbial fuel cell performance.

Neutrophil extracellular traps formation is associated with postoperative complications in neonates and infants undergoing congenital cardiac surgery

This study finds that neutrophil extracellular traps (NETs) formation is linked to postoperative complications in neonates and infants after congenital cardiac surgery.

Unveiling unique microbial nitrogen cycling and novel nitrification drivers in coastal Antarctica

This study identifies unique microbial nitrogen cycling mechanisms in coastal Antarctica, highlighting the role of comammox Nitrospira in nitrification.

Identification and characterization of a beta-1,4 Galactosidase from Elizabethkingia meningoseptica and its application on living cell surface

This study identifies and characterizes a beta-1,4 galactosidase from Elizabethkingia meningoseptica that can remove galactose from living cell surfaces, named geGalaseI.

Differential substrate affinity and catabolite repression enable preferential use of urea by ammonia-oxidizing bacteria

The paper shows that ammonia-oxidizing microorganisms use different regulatory strategies for ammonia and urea, enabling coexistence by minimizing competition.

Mass-immigration shapes the antibiotic resistome of wastewater treatment plants

The paper monitors antibiotic resistance genes in wastewater treatment plants and finds that mass-immigration of bacteria and ARGs from upstream units shapes ARG communities, with stochastic processes dominating their assembly.

Conventional dendritic cells 2, the targeted antigen-presenting-cell, induces enhanced type 1 immune responses in mice immunized with CVC1302 in oil formulation

This study shows that CVC1302 in oil formulation enhances Th1 immune responses by targeting antigen and inflammatory monocytes to lymph node inter-follicular regions and promoting IL-12 production by cDC2.

SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

TLR4/NF-κB Signaling Contributes to the Inflammation in Ovary and Inguinal Fats of Polycystic Ovary Syndrome

This study shows that TLR4/NF-κB signaling increases inflammation in ovarian and inguinal fat tissues of PCOS rats, worsening metabolic and reproductive symptoms.

Hydrological dynamics drive the transition of antibiotic resistance genes between particle-attached and free-living lifestyles in a deep freshwater reservoir

This study examines how seasonal hydrological changes affect the transition of antibiotic resistance genes between particle-attached and free-living lifestyles in a deep freshwater reservoir.

Cell detoxification of secondary metabolites by P4-ATPase mediated vesicle transport

The paper identifies a P4-ATPase gene in a fungus that mediates detoxification of immunosuppressants via vesicle transport, with cross-species resistance applications in plants and human health.

The multi-BRCT domain protein DDRM2 is required for homologous recombination in plants

A genetic screen in Arabidopsis identifies DDRM2, a multi-BRCT domain protein required for homologous recombination and regulated by SOG1.

Aggregation pheromone 4-vinylanisole promotes the synchrony of sexual maturation in female locusts

This study identifies 4-vinylanisole as an aggregation pheromone that promotes sexual maturation synchrony in gregarious female locusts through a juvenile hormone/vitellogenin pathway.

Non-canonical Function of a Hif-1α Splice Variant Contributes to the Sustained Flight of Locusts

This study identifies a non-canonical Hif-1 splice variant in locusts that supports sustained flight by promoting glucose oxidation and redox homeostasis under aerobic conditions.

Spatially-resolved transcriptomics analyses of invasive fronts in solid tumors

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

Correlational networking guides the discovery of cryptic natural product biosynthetic enzymes

The paper uses correlational networking to identify cryptic proteases involved in lanthipeptide biosynthesis across bacterial genomes.

DNMT family induced down-regulation of NDRG1 via DNA methylation and clinicopathological significance in gastric cancer

The paper investigates the relationship between NDRG1 expression, DNA methylation, and DNMT family in gastric cancer, finding DNMT1 correlates with prognosis.

A potent neutralizing human antibody reveals the N-terminal domain of the Spike protein of SARS-CoV-2 as a site of vulnerability

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

Dexmedetomidine mediates microRNA-185 to suppress ovarian cancer growth via inhibiting the SOX9/Wnt/β-catenin signaling pathway

This study identifies HAND2-AS1 as a tumor suppressor in cervical cancer by regulating miR-21 and ALEX1 to inhibit proliferation and EMT.

Diverse noncanonical PAMs recognized by SpCas9 in human cells

This study identifies multiple noncanonical PAMs recognized by SpCas9 in human cells, improving understanding of off-target mutation risks.

Mapping of transgenic alleles in plants using a Nanopore-based sequencing strategy

The paper introduces a Nanopore-based sequencing method to rapidly map transgenic alleles in the soybean genome, offering a high-throughput and cost-efficient approach.

Novel 5-Hydroxymethylcytosine Markers for Pancreatic Cancer

The paper investigates 5-hydroxymethylcytosine (5hmC) as a potential biomarker for pancreatic cancer, showing distinct distributions in tumor and adjacent tissues.