S. Saha

This paper shows that BCN057, a GSK3β modulator, selectively induces apoptosis in KRAS G12D mutant pancreatic cancer cells while protecting normal intestinal epithelium.

This study shows that isonicotinamide (INAM) extends yeast chronological lifespan by inhibiting nucleotide salvage pathways, leading to NAD+ accumulation and a hormetic stress response.

The paper identifies DRAIC, a tumor suppressive lncRNA, which inhibits NF-kB and activates AMPK-mTOR pathways to suppress cancer progression.

This study identifies quorum sensing signals from epibionts that induce bioactive peptides in Nostoc cyanobacteria, revealing interspecies communication in microbial communities.

This paper investigates F-type pyocins, showing they are diverse, potent bacteriocins with distinct killing specificities and potential as anti-bacterial therapeutics.

This study investigates the role of the anterior insula in social novelty recognition, showing its regulation by a local retinoic acid cascade and oxytocin signaling through a non-classical pathway.

This study identifies host proteins interacting with SARS-CoV-2 5' and 3' UTRs, revealing Lamp2a's antiviral role by reducing viral RNA levels.

The paper shows that the signal processing capacity of the cellular sensory machinery limits chemotactic accuracy under complex cues, using TGF-β and EGF as an example.

The paper identifies a new saponin-polybromophenol compound (CU1) from Cassia fistula bark that inhibits RNA polymerase in MDR bacteria, showing potential as an alternative antibiotic.

The paper reports the first interactome of human erythroid spectrin and finds no change in interacting protein identity but altered abundance under HbE disease conditions, with increased redox and chaperone proteins.

This study shows that Lgr5-positive rectal stem cells are radiosensitive and their transplantation mitigates radiation-induced rectal injury.

The paper investigates how the ratio of hydrophobic-hydrophilic and positive-negative charged residues at the lipid-water interface affects TRPV1 surface expression and channel-gating.

This study examines how introgressing a MYB28 variant from a wild Brassica species into broccoli affects sulphur metabolism and glucosinolate production.

This study uses CRISPR-Cas9 to edit myb28 in B. oleracea, showing reduced glucoraphanin accumulation in field-grown plants without affecting other sulphur metabolites.

This study shows that wild-type p53 amyloid formation leads to cellular transformation and tumor formation in mice by enhancing survival, proliferation, and migration while suppressing tumor suppressors.

This study identifies RSK-ABCB1 and HIF-1-FECH pathways regulated by MEK that reduce PpIX accumulation in cancer cells.

The paper identifies a pathway for repairing TOP3B DNA and RNA cleavage complexes, showing that TDP2 excises ubiquitinated TOP3Bccs after proteasomal degradation.

This study identifies mtp53's role in suppressing innate immune signaling by inhibiting TBK1, promoting tumorigenesis through immune evasion.

This study shows TRPA1 is expressed in T cells and modulates calcium levels and activation markers during T cell stimulation.

The paper identifies a resistance locus in Solanum lycopersicoides that recognizes type III effectors from Pseudomonas syringae and Ralstonia pseudosolanacearum, providing resistance to bacterial speck disease.

This study identifies TgFER2, a Ca2+ sensor essential for rhoptry secretion in Toxoplasma gondii, which is required for host cell invasion.

This paper identifies a novel sialylation site on Neisseria gonorrhoeae lipooligosaccharide that links HepII lactose expression with pathogenicity and vaccine potential.

The paper estimates the theoretical molecular weight of upconversion nanoparticles (UCNPs) based on their crystal structure and predicts size-dependent molecular weight distributions.

The paper shows that two phosphoglucomutase paralogs in Toxoplasma gondii regulate calcium-triggered microneme secretion but are not essential for completing the lytic cycle.