Author
X. Lian
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2020-2024 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 10 mutual co-author links9 papers
Recent·Most cited
pADP-ribosylation Regulates the Cytoplasmic Localization, Cleavage and Pro-apoptotic Function of HuR
K. Ashour, D. T. Hall, S. Mubaid, S. Bousque, X. Lian, J.-P. Gagne, S. Khattak, S. Di Marco, G. Poirier, I. E. Gallouzi
This study shows that PARP1/2-mediated PARylation regulates HuR's nuclear localization, cleavage, and pro-apoptotic function by binding to the HuR-PBS motif.
bioRxiv · Aug 7, 2023Cell Biology
Real-Time Spatiotemporal Measurement of Extracellular Signaling Molecules Using an Aptamer Switch-Conjugated Hydrogel Matrix
C. H. Park, I. A. P. Thompson, S. S. Newman, L. A. Hein, X. Lian, K. Fu, J. Pan, M. Eisenstein, H. T. Soh
The paper develops a hydrogel-based sensor to measure extracellular signaling molecules in real-time and demonstrates its use for cAMP in Dictyostelium discoideum.
bioRxiv · Jul 9, 2023Bioengineering
Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy
W. Sun, Y. Rassadkina, C. Gao, S. I. Collens, X. Lian, I. H. Solomon, S. S. Mukerji, X. G. Yu, M. Lichterfeld
The paper examines HIV-1 provirus persistence in CNS tissues during ART by analyzing multiple anatomical compartments in treated individuals.
bioRxiv · Jun 26, 2023Microbiology
Nuclear bodies protect phase separated proteins from degradation in stressed proteome
K. H. Jung, J. Sun, C.-H. Hsiung, X. Lian, Y. Liu, X. Zhang
The paper uses imaging methods to study how nuclear bodies protect TDP-43 from degradation during stress by monitoring its folding states in live cells.
bioRxiv · Apr 19, 2023 · PreprintBiochemistry
Robust genome editing via modRNA-based Cas9 or base editor in human pluripotent stem cells
T. Haideri, A. Howells, Y. Jiang, J. Yang, X. Bao, X. Lian
This study develops modRNA-based CRISPR systems for efficient genome editing in human pluripotent stem cells, achieving higher knockout efficiency than plasmid-based methods.
bioRxiv · May 24, 2022Bioengineering
Engineered human brown adipocyte microtissues improved glucose and insulin homeostasis in high fat diet-induced obese and diabetic mice
O. Wang, L. Han, H. Lin, M. Tian, S. Zhang, B. Duan, S. Chung, C. Zhang, X. Lian, Y. wang, Y. Lei
This study develops 3D human brown adipose microtissues that improve glucose and insulin homeostasis in obese and diabetic mice.
bioRxiv · Oct 11, 2021 · PreprintBioengineering
Efficacy of transoral laser surgery versus linear accelerator radiotherapy for the treatment of T1 glottic carcinoma: a meta-analysis of oncologic outcomes
J. Zhu, J. Shen, Z. Zheng, X. Lian, Z. Miao, K. Hu, F. Zhang
This meta-analysis compares oncologic outcomes of T1 glottic carcinoma treated with transoral laser surgery or linear accelerator radiotherapy, finding better overall survival and laryngeal preservation with surgery.
bioRxiv · Apr 20, 2020 · PreprintCancer Biology
Sulfopin, a selective covalent inhibitor of Pin1, blocks Myc-driven tumor initiation and growth in vivo
C. Dubiella, B. J. Pinch, D. Zaidman, T. D. Manz, E. Poon, S. He, E. Resnick, E. M. Langer, C. J. Daniel, H.-S. Seo, Y. Chen, S. B. Ficarro, Y. Jamin, X. Lian, S. Kibe, , N. London
Sulfopin, a selective Pin1 inhibitor, reduces tumor initiation and growth in neuroblastoma models by targeting c-Myc pathways.
bioRxiv · Mar 20, 2020 · PreprintCancer Biology