B. Duan

PerturBase: a comprehensive database for single-cell perturbation data analysis and visualization

PerturBase is a database that compiles and visualizes single-cell perturbation data from multiple studies, enabling analysis of genetic and chemical perturbations across millions of cells.

Characterization of RNA Polymerase II Trigger Loop Mutations using Molecular Dynamics Simulations and Machine Learning

This study uses molecular dynamics and machine learning to analyze RNA Polymerase II trigger loop mutations, finding that ML can predict phenotypes from sequences and MD data reveals structural changes linked to mutation effects.

Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events

This study identifies multiple recombination events between SARS-CoV-2 Omicron subvariants and other variants, suggesting co-infection and recombination drive viral evolution.

Engineered human brown adipocyte microtissues improved glucose and insulin homeostasis in high fat diet-induced obese and diabetic mice

This study develops 3D human brown adipose microtissues that improve glucose and insulin homeostasis in obese and diabetic mice.

Coupling Comprehensive Transcriptome-Metabolome Association and Phylogenetic Analysis Speed Dissecion of Polyphyllins Biosynthetic Pathway

This study identifies key genes in the polyphyllin biosynthetic pathway using transcriptome and metabolome data combined with phylogenetic analysis.

An early Cambrian ecdysozoan with a terminal mouth but no anus

This paper reclassifies Saccorhytus coronarius as an early Cambrian ecdysozoan lacking an anus, challenging previous deuterostome interpretations.

Chikungunya Virus Infection Impairs The Function Of Osteogenic Cells

This study shows that Chikungunya virus infects bone marrow stem cells and osteogenic cells, impairing their function and potentially contributing to bone pathology in infected individuals.

Chikungunya virus infection impairs osteogenic differentiation of bone marrow-derived mesenchymal stem cells