Author

Y.-M. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cancer Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:differential expression· 4 Approach:experimental assay· 4 Assay:metagenomics· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2

Frequent Co-Authors

J.-S. Zheng· 3 shared Z. Miao· 3 shared C.-w. Ling· 2 shared C.-Y. Chao· 2 shared F. XU· 2 shared G.-B. Lin· 2 shared H.-H. Liu· 2 shared T.-y. Sun· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMicrobiology

J.-S. Zheng

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

metaExpertPro: a computational workflow for metaproteomics spectral library construction and data-independent acquisition mass spectrometry data analysis

Y. Sun, Z. Xing, S. Liang, Z. Miao, L.-b. Zhuo, W. Jiang, H. Zhao, H. Gao, Y. Xie, Y. Zhou, L. Yue, X. Cai, Y.-m. Chen, J.-S. Zheng, T. Guo

metaExpertPro constructs metaproteomics spectral libraries and analyzes DIA-MS data, achieving high peptide quantification and low FDR in human fecal samples.

bioRxiv · Nov 29, 2023Microbiology

Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses

C.-B. Ma, C. Liu, Y.-J. Park, J. Tang, J. Chen, Q. Xiong, J. Lee, C. Stewart, D. Asarnow, J. Brown, M. A. Tortorici, X. Yang, Y.-H. Sun, Y.-M. Chen, X. Yu, , H. Yan

The paper identifies two European bat MERS-related coronaviruses that use ACE2 as their receptor, revealing a distinct binding mode and host tropism determinants.

bioRxiv · Oct 2, 2023Microbiology

Thermal cycling-hyperthermia down-regulates liposaccharide-induced inflammation in human blood and helps with clearance of herpes simplex virus type 1

Y.-Y. Kuo, G.-B. Lin, W.-T. Chen, Y.-M. Chen, H.-H. Liu, C.-Y. Chao

The paper evaluates thermal cycling-hyperthermia (TC-HT) and finds it reduces LPS-induced inflammation and enhances HSV-1 clearance by macrophages compared to standard hyperthermia.

bioRxiv · Dec 20, 2022 · PreprintImmunology

Thermal cycling hyperthermia sensitizes non-small cell lung cancer A549 cells to EGFR-tyrosine kinase inhibitor Erlotinib

G.-B. Lin, W.-T. Chen, Y.-Y. Kuo, H.-H. Liu, Y.-M. Chen, S.-J. Leu, C.-Y. Chao

This study shows that thermal cycling hyperthermia enhances the effectiveness of Erlotinib in A549 NSCLC cells by reducing IC50 and inducing cell cycle arrest.

bioRxiv · May 3, 2022Cancer Biology

Interpretable machine learning framework reveals novel gut microbiome features in predicting type 2 diabetes

W. Gou, C.-w. Ling, Z. Jiang, Y. He, Y. Fu, F. XU, Z. Miao, T.-y. Sun, J.-s. Lin, H.-l. Zhu, H. Zhou, Y.-m. Chen, J.-S. Zheng

The paper develops an interpretable machine learning framework to identify gut microbiome features predictive of type 2 diabetes, validated across multiple cohorts and linked to metabolic outcomes.

bioRxiv · Apr 5, 2020Microbiology

Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China

F. Wu, S. Zhao, B. Yu, Y.-M. Chen, W. Wang, Y. Hu, Z.-G. Song, Z.-W. Tao, J.-H. Tian, Y.-Y. Pei, M.-L. Yuan, Y.-L. Zhang, F.-H. Dai, Y. Liu, Q.-M. Wang, , Y.-Z. Zhang

The paper characterizes the complete genome of a novel coronavirus, WHCV, linked to a respiratory outbreak in Wuhan, finding it closely related to SARS-like bat coronaviruses.

bioRxiv · Jan 24, 2020 · PreprintPathology

The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for human complex diseases

F. Xu, Y. Fu, T.-y. Sun, Z. Jiang, Z. Miao, M. Shuai, W. Gou, C.-w. Ling, J. Yang, J. Wang, Y.-m. Chen, J.-S. Zheng

This study identifies host genetic variants associated with gut microbiome and examines causal relationships between gut microbiome and human complex diseases, revealing shared and distinct microbiome features.

bioRxiv · Dec 26, 2019Microbiology