Discover, rate, and discuss biology preprints.

This study investigates whether tau pathology precedes dopaminergic neurodegeneration in Parkinsonism by comparing groups with and without synucleinopathy.

This study shows that high-dose African-lineage Zika virus infection in late first trimester pregnant rhesus macaques causes frequent fetal loss.

The paper presents a real-time fungal spore monitoring system using digital holography, validated against manual traps for Alternaria spp. in a potato field.

This study develops a high-throughput phenotyping platform to assess Aphanomyces root rot resistance in field pea, identifies 260 SNPs associated with resistance, and discovers both known and novel genes involved in immunity.

This study shows acrylamide induces proteotoxic stress in CNS by suppressing FoxO1-mediated autophagy, leading to protein aggregation and neurodegeneration.

This paper establishes a reproducible murine pulmonary embolism model using small thrombi and evaluates the inflammatory response in the lung.

This study investigates the effects of cell-free fat extract (CEFFE) on osteoclastogenesis, showing its ability to reduce bone loss and inhibit osteoclast formation through antioxidant and calcium signaling modulation.

This study evaluates Alizarin Red as a fluorescent staining agent for visualizing nano and micro calcified structures in biological samples, finding it to be simple, reliable, effective, and cost-efficient.

This paper uses P-SHG microscopy and unsupervised clustering to identify tumor margins in lung tissue by analyzing ECM collagen structure.

This study correlates ultrasound imaging findings with histological fat cell counts to assess hepatic steatosis severity.

This study shows tegaserod maleate inhibits gastric cancer growth by targeting MEK1/2 in vitro and in a mouse model, with effects comparable to trametinib.

This study infects Mexican free-tailed bats with SARS-CoV-2 and finds they can become infected but do not show disease symptoms or transmit the virus.

This study examines how a visuospatial dual task affects interlimb coordination in Parkinson's disease patients during walking, finding minimal impact on coordination between limbs.

This study shows that TLR4/NF-κB signaling increases inflammation in ovarian and inguinal fat tissues of PCOS rats, worsening metabolic and reproductive symptoms.

This study identifies inducible bronchus-associated lymphoid tissue in SARS-CoV-2 infected rhesus macaques, suggesting local immunity plays a role in infection.

This study shows that increased hepatic Activin A expression reduces atherosclerosis by lowering cholesterol, inflammation, and fat accumulation in LDLR-/- mice on a Western diet.

This study investigates microRNA-mediated cross-kingdom regulation between Asian honey bee and microsporidian using RNA-seq and small RNA-seq data, identifying miRNA-target mRNA interactions and their roles in glycolysis, virulence, and immune response.

This study identifies stromal transdifferentiation of fibroblasts into adipocytes as the driver of lymph node lipomatosis, leading to vascular remodeling and immune dysfunction in aging.

This study identifies Hsp25/27 as a key mediator of mucosal healing by integrating host and microbial signals in intestinal epithelial cells following inflammatory injury.

This study identifies circRNAs in Asian honey bee midguts infected with Nosema ceranae and shows their role in regulating immune responses through miRNA targeting and pathway involvement.