Z. Pan

Stearoyl coenzyme A desaturase 1 (SCD1) regulates foot-and-mouth disease virus replication by modulating host cell lipid metabolism and 2C-mediated replication complex formation

This study shows SCD1 regulates FMDV replication by modulating lipid metabolism and 2C-mediated replication complex formation, suggesting it as a potential drug target for positive-sense RNA viruses.

Inhibition of Inflammatory Osteoclasts Enhances CGRP+TrkA+ Signaling and Accelerates Callus Remodeling in Osteoporotic Fractures

This study shows that inhibiting Cx3cr1+iOCs enhances CGRP+TrkA+ sensory signaling and accelerates callus remodeling in osteoporotic fractures.

Single-nucleus Multiomic Analyses Identifies Gene Regulatory Dynamics of Phenotypic Modulation in Human Aneurysmal Aortic Root

This study uses single-nucleus multiomic and spatial transcriptomic data to identify gene regulatory dynamics and key regulators in human aortic root tissue under healthy and Marfan syndrome conditions.

Potassium stimulates fruit sugar accumulation by increasing carbon flow in Citrus

This study shows potassium enhances sugar accumulation in citrus by boosting carbon flow between source and sink through phloem loading mechanisms.

The microbial community of rust layer biofilm was driven by seawater microbial community

The paper analyzes microbial communities in rust layer biofilm and seawater, identifying dominant taxa and their interactions, and provides insights into microbial corrosion mechanisms in marine environments.

Distinct Microstructural Heterogeneities Underpin Specific Micromechanical Properties in Human ACL Femoral and Tibial Entheses

This study identifies distinct microstructural and biomolecular features in ACL femoral and tibial entheses that contribute to their specific mechanical properties.

DnaK duplicates and regionally evolves for the increase of proteomic complexity in bacteria

The paper shows that DnaK duplication and regional evolution in bacteria increase proteomic complexity by expanding substrate specificity and function.

Camouflaging Endovascular Stents with an Endothelial Coat Using CD31 Domain 1-mimetic Peptides

This study coats endovascular stents with CD31 domain 1-mimetic peptides to promote endothelial integration and reduce blood cell activation, showing improved device integration and neo-arterial wall formation over 60 days.

Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants

This study identifies a molecular mechanism by which amyloplast sedimentation triggers LAZY protein relocalization to mediate gravity sensing in Arabidopsis.

Peptidoglycan from Bacillus anthracis Inhibits Human Macrophage Efferocytosis in Part by Reducing Cell Surface Expression of MERTK and TIM-3

Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence

This study determines the structure of RsmZ in complex with RsmA, revealing how RsmZ regulates virulence in Pseudomonas aeruginosa by modulating RsmA binding and gene expression.

Bioinformatics analysis of immune-related prognostic genes and immunotherapy in renal clear cell carcinoma

The paper identifies 4 immunoprognostic genes in ccRCC using bioinformatics analysis of public databases and validates their association with prognosis and immunotherapy response.

TLR4/NF-κB Signaling Contributes to the Inflammation in Ovary and Inguinal Fats of Polycystic Ovary Syndrome

This study shows that TLR4/NF-κB signaling increases inflammation in ovarian and inguinal fat tissues of PCOS rats, worsening metabolic and reproductive symptoms.

Fossil-explorer.com: An efficient interactive approach to exploring fossil data

Fossil-explorer.com is an interactive tool for exploring fossil data that addresses visual clutter and limited interaction, efficiently handling millions of data points.

Modulation of the gut microbiome by novel synthetic glycans for the production of propionate and the reduction of cardiometabolic risk factors

This paper identifies a synthetic glycan, KB39, that increases propionate production by the gut microbiome and reduces cardiometabolic risk factors in mice.

Experimental and mathematical models of intracellular calcium dynamics for evaluating combined anticancer effects of Afatinib and RP4010 in esophageal cancer

A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

Nrf2 mediated ER-phagy protects against oxidative damage in intervertebral disc degeneration

This study identifies Nrf2/FAM134B-mediated ER-phagy as a protective mechanism against oxidative damage in intervertebral disc degeneration.

Profiling tumor immune microenvironment of non-small cell lung cancer using multiplex immunofluorescence

This study profiles the tumor immune microenvironment of NSCLC using multiplex immunofluorescence, identifying three immune subtypes and an immune-related risk score for prognosis prediction.

A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

Comparative genomic analyses provide clues to capsule switch in Streptococcus suis

This study identifies capsule switch in Streptococcus suis strains through comparative genomic analyses, revealing genetic exchange between SS2, SS3, and SS7 strains.

Momilactone B inhibits Arabidopsis growth and development via disruption of ABA and auxin signaling

Momilactone B inhibits Arabidopsis growth and development by disrupting ABA and auxin signaling, highlighting the role of phytohormones in allelopathic responses.

Genomic insight into biogeographic history, divergence, and adaptive potential of G. purpurascens, a forgotten landrace of G. hirsutum

This study analyzes the genomic structure and adaptive potential of G. purpurascens, a landrace of G. hirsutum, to understand its biogeographic history and divergence from modern cultivars.

Salmonella Enteritidis Effector AvrA suppresses autophagy by reducing Beclin-1 protein

This study shows that Salmonella Enteritidis effector AvrA suppresses autophagy by reducing Beclin-1 protein via the JNK pathway, promoting bacterial survival in host cells.