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This study identifies Mindin as a key driver of fibrosis in a new mouse model of systemic sclerosis, showing its role in inducing inflammation and collagen production in fibroblasts.

This study identifies dermal fibroblasts as the origin of skin lesions in Carney complex by showing their pro-melanogenic activity under PKA signaling disruption.

This study uses single-cell RNA sequencing to identify immune and smooth muscle cell populations in CTEPH thrombus, revealing inflammatory mechanisms and a potential therapeutic target.

This study shows that the LPS-TLR4 pathway promotes NETs formation in AACLF, exacerbating liver injury through mechanisms involving gut-derived LPS and neutrophil activity.

This study shows that iron deficiency in mice with metabolic syndrome causes heart failure with ectopic cardiac calcification, which is reduced by etidronate.

This study investigates the role of YAP in NPH-like kidney disease and finds that YAP inhibition is not therapeutic, suggesting LKB1 and YAP are parallel regulators of a harmful pathway.

This study shows that proteasome subunit PSMB4 is critical for brown adipocyte differentiation and function, with its loss causing inflammation and adipogenesis disruption via ATF3 activation.

The paper uses transcranial Doppler ultrasound to assess brain aneurysm progression in mouse models, finding decreased blood velocities and tortuous arteries correlate with aneurysm formation.

This paper identifies a short linear motif (SLiM) in the Ehrlichia TRP120 effector that mimics Notch ligands to activate Notch signaling in human monocytes.

The paper shows that kidney cells reprogram iron metabolism to prevent severe malarial anemia by supporting erythropoiesis.

The paper introduces a method for preserving placental specimens in low-resource settings, enabling malaria detection and nucleic acid analysis with 92% success.

This study examines how mutant HTT affects skeletal muscle regeneration in R6/2 HD mice, finding reduced myofiber width and altered satellite cell function.

This paper develops an AI model for tumor cellularity evaluation in lung adenocarcinoma, validated through collaboration with pathologists to improve accuracy.

This study shows that anti-thrombotic treatment improves antibiotic effectiveness in a humanized meningococcemia model by enhancing blood flow and reducing bacterial resistance.

This study compares SARS-CoV-2 infection outcomes in immunocompetent and immunocompromised hamsters, finding that histopathological changes better predict disease severity than viral load or antibody levels.

This study shows Hantaan virus uses mitochondrial OXPHOS for replication, driven by AKT activation and PNPT phosphorylation.

This study shows that metabolic rescue with nicotinamide riboside improves mitochondrial encephalo-cardiomyopathy in mouse and human iPSC models of Leigh syndrome.

This paper introduces MATE, a label-free 3D histological imaging technique for whole organs, enabling high-resolution visualization and quantitative analysis of tissue structures without staining or clearing.

This study computationally analyzes mutations in the SARS-CoV-2 B.1.1.7 variant to show increased binding affinity and stability with the hACE-2 receptor, suggesting higher virulence.