Author

C. Combs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Bioengineering· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:C. elegans· 2 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Research Focus:dimensionality reduction· 2 Organism:Drosophila· 2 Research Focus:imputation· 2 Organism:mouse· 2

Frequent Co-Authors

D. Colon-Ramos· 2 shared H. Shroff· 2 shared J. Liu· 2 shared L. Zhang· 2 shared P. La Riviere· 2 shared R. Christensen· 2 shared X. Han· 2 shared Y. Su· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

D. Colon-Ramos

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Deep learning-based aberration compensation improves contrast and resolution in fluorescence microscopy

M. Guo, Y. Wu, C. M. Hobson, Y. Su, S. Qian, E. Krueger, R. Christensen, G. Kroeschell, J. Bui, M. Chaw, L. Zhang, J. Liu, X. Hou, X. Han, Z. Lu, , H. Shroff

This paper introduces a deep learning method to correct optical aberrations in fluorescence microscopy, improving image quality and enabling better downstream analysis.

bioRxiv · Oct 15, 2023 · PreprintBioengineering

Post-Transplant Administration of G-CSF Impedes Engraftment of Gene Edited Human Hematopoietic Stem Cells by Exacerbating the p53-Mediated DNA Damage Response

D. Araki, V. Chen, N. Redekar, C. Salisbury-Ruf, Y. Luo, P. Liu, Y. Li, R. Smith, P. Dagur, C. Combs, A. Larochelle

This study shows that post-transplant G-CSF administration impairs engraftment of CRISPR-edited HSPCs by worsening the p53 DNA damage response, but not unedited or lentiviral-transduced HSPCs.

bioRxiv · Jun 29, 2023Cell Biology

TPR domain assigns versatility of BcTir/Tpr system against viral infection

Y. Liu, C. Zhang, N. Khudaverdyan, J. Wang, L. Zhang, M. Golovko, S. Golovko, A. Guo, J. Song, M. Wu, C. Combs

The paper identifies the BcTir/Tpr system in Bacillus cereus as a defense mechanism against phage infection, showing BcTpr's dual role in NAD+ depletion and cADPR isomer production.

bioRxiv · May 26, 2023 · PreprintMicrobiology

Mechanical activation of mitochondrial energy metabolism during cell differentiation

Z.-H. Wang, C. Combs, W. Zhao, J. Knutson, M. Lilly, H. Xu

The paper shows mechanical forces from surrounding tissue activate mitochondrial energy metabolism during cell differentiation in Drosophila.

bioRxiv · Mar 23, 2022 · PreprintCell Biology

Pericentrin is a Kinesin-1 Activator that Drives Centriole Motility

M. R. Hannaford, R. Liu, N. Billington, Z. T. Swider, B. J. Galletta, C. J. Fagerstrom, C. Combs, J. R. Sellers, N. M. Rusan

The paper identifies Pericentrin-Like-Protein (PLP) as a Kinesin-1 activator that drives centriole motility during interphase.

bioRxiv · Jan 12, 2022 · PreprintCell Biology

Multiview super-resolution microscopy

Y. Wu, X. Han, Y. Su, M. Glidewell, J. S. Daniels, J. Liu, T. Sengupta, I. Rey-Suarez, R. Fischer, A. Patel, C. Combs, J. Sun, X. Wu, R. Christensen, C. Smith, , H. Shroff

This paper introduces a multiview super-resolution microscopy approach that enhances confocal microscopy resolution and reduces phototoxicity across multiple scales.

bioRxiv · May 21, 2021 · PreprintBioengineering