Author

K. Konstantopoulos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

S. X. Sun· 3 shared J. Yang· 2 shared M. I. Choudhury· 2 shared Y. Li· 2 shared A. C. N. Vasconcelosi· 1 shared A. Cho· 1 shared A. Gill· 1 shared A. J. Crawford· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersBiophysics

S. X. Sun

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Confinement, jamming, and adhesion in cancer cells dissociating from a collectively invading strand

W. Wang, R. A. Law, E. Perez Ipina, K. Konstantopoulos, B. A. Camley

This study investigates how cancer cells dissociate from an invading front, finding that single-cell rupture is most common and influenced by adhesion and chemotaxis.

bioRxiv · Jun 28, 2024Cell Biology

Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation

Q. Ni, Z. Ge, Y. Li, G. Shatkin, J. Fu, K. Bera, Y. Yang, Y. Wang, A. Sen, Y. Wu, A. C. N. Vasconcelosi, A. P. Feinberg, K. Konstantopoulos, S. X. Sun

This study identifies a mechanism where cytoskeletal activation of NHE1 drives secondary volume increase and affects cell proliferation in response to hypotonic stress.

bioRxiv · Aug 31, 2023Biophysics

Serine synthesis pathway upregulated by E-cadherin is essential for the proliferation and metastasis of breast cancers

G. Lee, C. Wong, A. Cho, J. J. West, A. J. Crawford, G. C. Russo, B. R. Si, J. Kim, L. Hoffner, C. Jang, M. Jung, R. D. Leone, K. Konstantopoulos, A. J. Ewald, D. Wirtz, S. Jeong

This study shows that E-cadherin upregulates the serine synthesis pathway in breast cancer cells, supporting proliferation and metastasis by providing metabolic precursors and resistance to oxidative stress.

bioRxiv · May 24, 2023 · PreprintCancer Biology

Cells in the Polyaneuploid Cancer Cell (PACC) state have increased metastatic potential

M. M. Mallin, N. Kim, M. I. Choudhury, S. J. Lee, S. S. An, S. X. Sun, K. Konstantopoulos, K. J. Pienta, S. R. Amend

The paper identifies Polyaneuploid Cancer Cells (PACCs) as metastasis-competent cells through increased motility, elasticity, and survival in circulation.

bioRxiv · Sep 16, 2022Cancer Biology

Sculpting rupture-free nuclear shapes in fibrous environments

A. Jana, A. Tran, A. Gill, R. Kapania, K. Konstantopoulos, A. Nain

The paper investigates how nuclei adapt to fibrous environments by studying cytoskeleton-mediated force transmission and its effect on nuclear shape.

bioRxiv · Oct 19, 2021Cell Biology

Post-EMT: Cadherin-11 mediates cancer hijacking fibroblasts

W. Kang, Y. Fan, Y. Du, E. A. Tonkova, Y.-H. Hsu, K. V. Tan, S. Alexander, B. S. Wong, H. Yang, J. Luo, K. Yao, J. Yang, X. Hu, T. Liu, Y. Gan, , Z. Gu

This study identifies cadherin-11 as a mediator of cancer cell hijacking of fibroblasts post-EMT, enhancing invasion and metastasis in solid tumors.

bioRxiv · Aug 27, 2020 · PreprintCancer Biology

Trans-epithelial Fluid Pumping Performance of Renal Epithelial Cells and Mechanics of Cystic Expansion

M. I. Choudhury, Y. Li, P. Mistriotis, E. E. Dixon, J. Yang, D. Maity, R. Walker, M. Benson, L. Martin, F. Koroma, F. Qian, K. Konstantopoulos, O. M. Woodward, S. X. Sun

This study uses a microfluidic platform to show renal epithelial cells generate hydraulic pressure gradients, with PKD cells showing reversed fluid flow and higher stall pressure.

bioRxiv · Aug 6, 2019Biophysics