J. Xia

This study shows that HBV infection enhances the hexosamine biosynthesis pathway, leading to O-GlcNAcylation of SAMHD1, which boosts antiviral immunity against HBV and HIV-1.

The paper shows that stress-induced myonectin improves glucose homeostasis by inhibiting glycemic response to epinephrine and enhancing insulin sensitivity in adipose tissues.

This study identifies a glucocorticoid-cytokine signaling circuit in the tumor microenvironment that promotes CD8+ T cell dysfunction and correlates with poor response to checkpoint blockade in melanoma.

This study uses single-cell RNA-seq to analyze human infant retina, identifying cell types, communication networks, and developmental changes, providing a resource for retinal research and regenerative medicine.

This study uses single-cell RNA sequencing to analyze the cellular diversity and molecular markers in the retina of a trisomy 21 fetus, revealing communication networks and novel markers.

This study compares lane keeping and speed control between post-stroke and normal older drivers using vehicle tracking data, finding higher lane deviation in complex tasks for post-stroke drivers but no speed differences.

This study shows low-dose IFN-γ promotes tumor stemness in NSCLC via ICAM1-PI3K-Akt-Notch1 pathway, while high-dose IFN-γ induces apoptosis through JAK1-STAT1-caspase pathway.

The paper shows ciprofloxacin induces antibiotic-resistant mutations by creating a subpopulation of cells with activated sigma-S response, which allows error-prone repair and generates cross-resistant mutants.

The paper identifies DNA-damaging proteins in E. coli and their human homologs, showing they promote endogenous DNA damage and are overrepresented in cancer drivers.