Author

Z. Lou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Research Focus:protein structure prediction· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1

Frequent Co-Authors

B. Wang· 1 shared B. Zhang· 1 shared C. Peng· 1 shared C. Zhu· 1 shared D. K. Ma· 1 shared F. Liu· 1 shared F. Yang· 1 shared G. Chen· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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1 shared paperCell Biology

B. Wang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

AlphaFold2-Guided Functional Screens Reveal a Conserved Antioxidant Protein at ER Membranes

Z. Ji, T. Pandey, H. d. Belly, B. Wang, O. K. Weiner, Y. Tang, S. Guang, J. Yao, S. Xu, Z. Lou, T. Goddard, D. K. Ma

The paper identifies ERGU-1 as a conserved antioxidant protein at ER membranes using AlphaFold2 and functional screens in C. elegans, showing its role in H2O2 detoxification and antioxidant defense.

bioRxiv · Jun 19, 2024 · PreprintCell Biology

Emerging Evidence for Poxvirus-Mediated Unfolded Protein Response: Lumpy Skin Disease Virus Maintains Self-replication by Activating PERK and IRE1

J. Tan, Y. Liu, F. Yang, G. Chen, Y. Fang, X. He, Z. Lou, H. Jia, Z. Jing, W. Li

This study shows that lumpy skin disease virus activates PERK and IRE1 pathways to support its replication, suggesting potential therapeutic targets for poxvirus infections.

bioRxiv · Jun 27, 2022Microbiology

Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors

G. Xu, R. Zhang, H. Li, K. Yin, X. Ma, Z. Lou

This study determines the cryo-EM structures of AAV9 and AAVPHP.eB in complex with their receptor AA VR, revealing molecular details of receptor recognition and explaining enhanced CNS transduction.

bioRxiv · Jan 23, 2022Microbiology

Tumor protein D52 (TPD52) affects cancer cell metabolism by negatively regulating AMPK.

Y. Chen, C. Peng, W. Tan, J. Yu, J. Zayas, Y. Peng, Z. Lou, H. Pei, L. Wang

This study shows TPD52 inhibits AMPK activity, leading to metabolic defects in mice, highlighting its role in cancer metabolism.

bioRxiv · Mar 9, 2021Cell Biology

Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target

Y. Gao, L. Yan, Y. Huang, F. Liu, Y. Zhao, L. Cao, T. Wang, Q. Sun, Z. Ming, L. Zhang, J. Ge, L. Zheng, Y. Zhang, H. Wang, Y. Zhu, , Z. Rao

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

bioRxiv · Mar 16, 2020 · PreprintBiochemistry