M. Luo

This paper identifies SAM competitive inhibitors of SARS-CoV-2 nsp14 methyltransferase and characterizes their mechanism, guiding the development of selective bi-substrate inhibitors.

This study identifies the ZmCd1 gene controlling cadmium accumulation in maize grains and develops molecular markers for breeding low-Cd maize varieties.

This study identifies PRMT1-mediated methylation of DUSP4 as a regulator of p38 MAPK activity, influencing megakaryocyte differentiation and thrombocytopenia in myelodysplastic syndromes.

The paper identifies lysine isobutyrylation as a new histone modification mark and shows its role in epigenetic regulation and cellular physiology.

This study reconstructs the evolutionary history of insect metallothioneins by developing a BLAST pipeline and analyzing phylogenetics and synteny, revealing lineage-specific duplications and a previously unknown MT variant.

This study shows that Alk1 mutant endothelial cells expand clonally in mouse brain arteriovenous malformations (AVMs) and that BM-derived Alk1 mutant ECs can cause AVMs.

This study identifies and characterizes ZmCPAs in maize, showing their roles in salt tolerance through expression analysis and functional validation.

The paper shows that sex pheromones from Cnaphalocrocis medinalis reduce the attraction of Chilo suppressalis males to their own pheromones, suggesting a potential method for pest control.

A vaccine targeting viral protease cleavage sites provides >80% protection against vaginal SIVmac251 infection in macaques by inducing T cell responses and a protective immune environment.

The paper develops individualized ctDNA fingerprint panels to monitor treatment response and recurrence across multiple cancer types using whole-exome sequencing data.

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

This study reveals dynamic conformational landscapes of SETD8 using X-ray structures and molecular simulations, showing how protein dynamics influence catalysis and cancer-associated mutations.

This paper identifies BceR as a key regulator in Group B Streptococcus virulence, antimicrobial resistance, and stress response through functional analysis of a non-invasive strain.