Author

N. Navin

The University of Texas MD Anderson Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:experimental assay· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:clustering· 2

Frequent Co-Authors

M. Hu· 2 shared A. Aktipis· 1 shared A. Aparicio· 1 shared A. Rumandla· 1 shared Alastair Mark ThompsoniD· 1 shared Allison M. AripoliiD· 1 shared Andrew K. GodwiniD· 1 shared Ashley I. HuppeiD· 1 shared

Activity by Year

2020-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

M. Hu

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Cellular stemness identifies high-risk ductal carcinoma in situ and offers a therapeutic interception opportunity

Emily Schueddig, Veena Kochat, Emre Arslan, Y. Dallas, P. Yang, William Pedron, Z G Li, Reagan Henry, Jerome Lin, Mahinur Mattohti, Rashna Madan, Timothy A. Fields, S. Golem, S. A. Khan, Jamie Lynn Wagner, , Fariba Behbod

This study identifies stemness features in luminal hormone-responsive cells within DCIS that correlate with invasive progression and shows that targeting FOXA1 reduces tumor growth.

bioRxiv · May 16, 2026 · PreprintCancer Biology

Reconstructing mutational lineages in breast cancer by multi-patient-targeted single cell DNA sequencing

N. Navin, J. Leighton, M. Hu, E. Sei, F. Meric-Bernstam

This study develops a multi-patient-targeted scDNA-seq method to profile informative mutations in breast cancer and identifies mutational lineages across multiple tumors.

bioRxiv · Nov 16, 2021Cancer Biology

Transcriptional Inactivation of TP53 and the BMP Pathway Mediates Therapy-induced Dedifferentiation and Metastasis in Prostate Cancer

H. Han, Y. Wang, J. N. Curto, S. Gurrapu, S. Laudato, A. Rumandla, G. Chakraborty, X. Wang, H. Chen, Y. Jiang, D. Kumar, E. G. Caggiano, B. Zhang, Y. Ji, S. N. Maity, , F. G. Giancotti

The paper identifies a novel subtype of therapy-induced prostate cancer cells with hybrid E/M and stem-like traits, showing their dependency on HER2/3 signaling and resistance to AR inhibition.

bioRxiv · Apr 14, 2021 · PreprintCancer Biology

Single-cell multimodal glioma analyses reveal epigenetic regulators of cellular plasticity and environmental stress response

K. C. Johnson, K. J. Anderson, E. T. Courtois, F. Barthel, F. S. Varn, D. Luo, M. Seignon, E. Yi, H. Kim, M. Estecio, M. Tang, N. Navin, R. Maurya, C. Ngan, N. Verburg, , R. Verhaak

The paper integrates multi-omic data from gliomas to show that epigenetic instability and transcriptional disruption are linked to tumor aggressiveness and environmental stress response.

bioRxiv · Jul 22, 2020Cancer Biology

Clonal Evolution of Acute Myeloid Leukemia Revealed by High-Throughput Single-Cell Genomics

K. Morita, F. Wang, K. Jahn, J. Kuipers, Y. Yan, J. Matthews, L. Little, C. Gumbs, S. Chen, J. Zhang, X. Song, E. Thompson, K. Patel, C. Bueso-Ramos, C. D. DiNardo, , K. Takahashi

This study uses single-cell DNA sequencing to analyze clonal diversity in AML, revealing mutation co-occurrence, mutual exclusivity, and evolutionary patterns linked to treatment resistance and poor prognosis.

bioRxiv · Feb 7, 2020Cancer Biology

Transient Commensal Clonal Interactions Can Drive Tumor Metastasis

S. Naffar-Abu Amara, H. J. Kuiken, L. M. Selfors, T. Butler, M. L. Leung, C. T. Leung, E. P. Kuhn, T. R. Kolarova, C. Hage, K. Ganesh, R. Foster, B. R. Rueda, A. Aktipis, P. T. Spellman, T. Ince, , J. S. S. Brugge

The paper shows that transient interactions between non-tumorigenic and tumorigenic clones can drive metastasis through amphiregulin-mediated mesothelial clearance.

bioRxiv · Jan 16, 2020 · PreprintCancer Biology