Author

J. Matthews

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 2 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

F. Wang· 3 shared G. Garcia-Manero· 3 shared J. Zhang· 3 shared K. Takahashi· 3 shared L. Little· 3 shared M. Konopleva· 3 shared A. Futreal· 2 shared C. Gumbs· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

F. Wang

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Inflammation-Induced Claudin-2 Upregulation Limits Pancreatitis Progression by Enhancing Tight Junction-Controlled Pancreatic Ductal Transport

S. Kesaraju, Y. Li, J. Xing, M. Tracy, K. Wannemo, A. Holder, P. Zhao, M. A. Khan, J. Kainov, N. Rana, M. Sidahmed, S. Hyoju, L. Smith, J. Matthews, S. Tay, , C. Weber

This study shows CLDN2 upregulation during pancreatitis limits disease progression by enhancing tight junction-controlled fluid transport in pancreatic ductal epithelium.

bioRxiv · Sep 1, 2023 · PreprintPathology

Digital data repository and automatic analysis framework for FDOPA PET neuroimaging

G. Nordio, R. Easmin, A. Giacomel, O. Dipasquale, D. Martins, S. Williams, F. E. Turkheimer, O. Howes, S. Jauhar, M. Rogdaki, R. McCutcheon, S. Kaar, L. Vano, G. Rutigliano, I. Angelescu, , M. Veronese

The paper develops a digital data repository and automated analysis framework for FDOPA PET neuroimaging to quantify dopamine synthesis capacity, showing high agreement with manual analysis and good reproducibility.

bioRxiv · Apr 14, 2022 · PreprintBioengineering

Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia

F. Wang, K. Morita, C. DiNardo, K. Furudate, T. Tanaka, Y. Yan, K. Patel, K. MacBeth, B. Wu, G. Liu, M. Frattini, J. Matthews, L. Little, C. Gumbs, X. Song, , K. Takahashi

The paper identifies leukemia stemness and co-occurring mutations as drivers of resistance to IDH inhibitors in AML through genomic analyses of treated patients.

bioRxiv · Oct 27, 2020Cancer Biology

Single-cell Characterization of Acute Myeloid Leukemia and its Microenvironment Following PD-1 Blockade Based Therapy

H. A. Abbas, D. Hao, K. Tomczak, P. Baroodia, J. Im, P. K. Reville, Z. Alaniz, W. Wang, R. Wang, F. Wang, G. Al-Atrash, K. Takahashi, J. Ning, M. Ding, J. Matthews, , A. Futreal

This study analyzes single-cell RNA and TCR profiles from AML patients before and after PD-1 blockade therapy to identify factors influencing response and resistance.

bioRxiv · Sep 3, 2020Cancer Biology

Clonal Evolution of Acute Myeloid Leukemia Revealed by High-Throughput Single-Cell Genomics

K. Morita, F. Wang, K. Jahn, J. Kuipers, Y. Yan, J. Matthews, L. Little, C. Gumbs, S. Chen, J. Zhang, X. Song, E. Thompson, K. Patel, C. Bueso-Ramos, C. D. DiNardo, , K. Takahashi

This study uses single-cell DNA sequencing to analyze clonal diversity in AML, revealing mutation co-occurrence, mutual exclusivity, and evolutionary patterns linked to treatment resistance and poor prognosis.

bioRxiv · Feb 7, 2020Cancer Biology

Regulation of Decellularized Tissue Remodeling via Scaffold-Mediated Lentiviral Delivery in Anatomically-Shaped Osteochondral Constructs

C. Rowland, K. A. Glass, A. R. Ettyreddy, C. C. Gloss, J. Matthews, N. P. T. Huynh, F. Guilak

This study uses scaffold-mediated lentiviral delivery to control inflammation and tissue formation in osteochondral constructs.

bioRxiv · Feb 8, 2018Bioengineering

Type-2 CD8+ T lymphocytes responsive to PGD2 and LTE4 in severe eosinophilic asthma

B. Hilvering, T. S. Hinks, L. Stoger, E. Marchi, M. Salimi, R. Shrimanker, W. Liu, W. Chen, J. Luo, S. Go, T. Powell, J. Cane, S. Thulborn, A. Kurioka, T. Leng, , L. Xue

The paper identifies type-2 CD8+ T cells (Tc2) enriched in severe eosinophilic asthma and shows PGD2 and LTE4 drive their recruitment and activation, contributing to eosinophilia.

bioRxiv · Jan 12, 2018Immunology