Y. Lee

This study demonstrates that ThiL is essential for thiamine biosynthesis and salvage in Pseudomonas aeruginosa and identifies inhibitors with potential antibacterial activity.

This study uses a CRISPR screen in mouse Tregs to identify genes regulating Foxp3 expression, finding Usp22 and Atxn7l3 as stabilizers and Rnf20 as a destabilizer.

This study uses single-molecule techniques to show that yeast CHD1 remodels nucleosomes through unique DNA unwrapping and translocation dynamics involving ATP binding and hydrolysis.

This study investigates how reduced SERCA2a expression and activity contribute to impaired lymphatic contractile activity in a metabolic syndrome rat model.

This study shows that Mul1 suppresses Nlrp3 inflammasome activation by ubiquitinating and degrading Asc, thereby preventing excessive inflammation.

This study investigates the effect of 6-O-galloylsalidroside on alcoholic steatosis and liver injury in mice, finding it reduces lipid accumulation and liver damage.

This paper introduces a method to control axonal endosome transport in live neurons using magnetic forces, revealing insights into dynein function and endosome dynamics.

This paper develops CRISPR-based split-gene drives in Aedes aegypti with high cleavage and transmission rates, demonstrating their potential for safe and reversible population control.

The paper develops a high-throughput γ-H2AX assay using imaging flow cytometry to measure DNA double-strand break repair kinetics in human blood cells after ionizing irradiation.

This study uses mass cytometry to analyze how silver nanoparticles interact with different human immune cells at the single-cell level, revealing differences in association and toxicity across cell types.

This paper reports the cryo-EM structure of the human LAT1-CD98hc heterodimer, revealing its architecture and interactions, and maps disease mutations to explain congenital disorders.

This study uses single-particle tracking to show that KRas diffusion and trafficking are regulated by nested membrane nanodomains in U2OS cells.

The paper quantifies sustained Ca2+ mobilizations in cell-cell communication during wound healing and identifies pannexin channels and purinoreceptors as key regulators.

This paper reports a case of C. deuterogattii VGIIa infection in a U.S. patient linked to travel to the PNW outbreak region and associated with anti-GM-CSF autoantibodies.

This study investigates gut microbiota changes and lauric acid effects in chickens challenged with Clostridium perfringens and Eimeria, finding that Clostridium sensu stricto 1 overgrowth contributes to necrotic enteritis.

This study shows RUNX3 regulates chromatin dynamics at the restriction point by opening and closing target loci through recruitment of chromatin modifiers, influencing cell cycle progression and tumor development.

The paper determines the cryo-EM structure of the adenosine A2A receptor bound to NECA and coupled to an engineered G protein, revealing structural similarities and flexibility compared to a crystal structure.

This study uses molecular dynamics simulations to reveal the free energy landscape and mechanism of the triose-phosphate/phosphate translocator's transport cycle.

This study determines the crystal structures of TPT bound to substrates, revealing the molecular basis of its strict 1:1 exchange mechanism.

The paper reports multiple pepper genomes and finds that retroduplication via LTR-retrotransposons drives expansion of disease resistance genes in plants.

This study uses molecular dynamics simulations to investigate how DMSO affects water structure and dynamics near phospholipid bilayers, revealing discrepancies between experimental and simulation results.