Y. Lee

This study determines the solution structure of SARS-CoV-2 nsp7 at pH 7.0 using NMR spectroscopy and identifies pH-dependent structural changes in the protein.

The paper enhances CRISPR-Cas12a system specificity and efficiency using a chimeric DNA-RNA guide, achieving 7.41 and 7.60 times improvements respectively.

This study evaluates two vaccinia virus-based SARS-CoV-2 vaccines in mice and hamsters, showing they induce neutralizing antibodies and protect against infection.

This study shows that capicua (CIC) regulates thymic T cell development by controlling positive and negative selection and TCR signaling, preventing autoimmunity.

A co-fractionation mass spectrometry pipeline predicts compositions of cytosolic protein complexes in early rice seed development.

This study shows that daily administration of LuCI, an oral gut coating agent, leads to weight loss and improved insulin sensitivity in a rat model of diet-induced obesity.

This study develops and tests human embryonic stem cell-derived chondrocytes for long-term repair of porcine articular cartilage, showing improved functionality compared to current methods.

The paper performs bidirectional CRISPR screens to identify host factors regulating SARS-CoV-2, MERS-CoV, and seasonal coronaviruses, revealing new anti-viral proteins and general coronavirus cofactors.

This study identifies Ca2+-mediated higher-order assembly of b0,+AT-rBAT as critical for system b0,+ trafficking and reveals its role in type I cystinuria.

This study evaluates the neutralization capacity of hyperimmune immunoglobulins and convalescent plasma against SARS-CoV-2 and its variants, finding reduced effectiveness against certain variants with hCoV-2IG showing better cross-neutralization than convalescent plasma.

This study examines the population dynamics between Physarum polycephalum and a red yeast in a spatial ecosystem, revealing an inverse growth relationship and oscillatory dynamics.

This study identifies a redox-dependent mechanism by which AMPK dysregulation leads to metabolic failure in glucose-deprived cancer cells, specifically in xCT-high expressing lines.

This study demonstrates that 3D8 scFv has antiviral activity against oseltamivir-resistant influenza A virus in cell and mouse models.

This study analyzes the effects of seed coat color and seed weight on protein, oil, and fatty acid contents in soybean germplasms, finding significant variations in fatty acids and a trade-off between oleic and linoleic acids.

This study shows IL-23R signaling enables Th1 cells to acquire a colitogenic phenotype, distinct from Th17 cells, and identifies CD160 as a key regulator.

This study identifies NEK2-EZH2 signaling as critical for glioblastoma tumor core progression and resistance, and presents a novel inhibitor CMP3a that shows therapeutic potential.

This study demonstrates that 3D8 scFv inhibits replication of SARS-CoV-2, HCoV-OC43, and PEDV in vitro through nucleic acid hydrolysis.

The paper uses high-resolution 3D imaging to show that subcellular organization in liver cells changes with obesity, affecting metabolism.

This paper shows that simultaneously reducing PD-1 and TIGIT in CAR T cells improves their antitumor activity and memory phenotype in mouse models.

This study identifies IP3R over-activation in adipocytes as a key mechanism linking obesity, inflammation, and insulin resistance, suggesting therapeutic targeting of Ca2+ homeostasis.

The paper evaluates a new silicone airway stent (GINA stent) in pigs, showing improved mechanical properties and comparable performance to the Dumon stent.

This study shows that AdCOVID, an intranasal vaccine, induces both systemic and mucosal immunity against SARS-CoV-2 in mice.

This paper develops a rapid tracheal stenosis model in pigs using cuff overpressure and electrocautery, achieving stenosis in 7 days with combined treatment.

This paper introduces compressed FLIM for high-speed, high-resolution live-cell imaging, achieving 100 Hz imaging with reduced photobleaching and motion artifacts.

The paper identifies stereotypic VH clonotypes against SARS-CoV-2 RBD in patients and healthy individuals, showing their pre-existing presence in the healthy population.

The paper develops an instrument to assess HIV-related knowledge and psychological adjustment, finding specific knowledge and cognitive traits correlate with anti-retroviral adherence.

This study identifies peroxidases as essential for Casparian strip lignification in Arabidopsis, while laccases are not required for this process.

This study identifies an endocrine-hepato-muscular metabolic cycle linking hyperglycemia and skeletal muscle atrophy in type 2 diabetes through dysregulated alanine metabolism and ALT enzyme activity.

This study analyzed gait parameters of healthy rhesus monkeys using a pressure-sensing walkway, revealing forelimb dominance in weight distribution and symmetric gait patterns.

This study develops an in vitro muscle parabiosis system to identify rejuvenating factors in aged muscle stem cells by mimicking systemic and local signals.