Y.-L. Li

Cytoophidia influence cell cycle and size in Schizosaccharomyces pombe

This study shows that cytoophidia of CTPS regulate cell cycle and size in S. pombe by affecting G2/M transition and cell growth genes.

Super-resolution imaging reveals dynamic reticular cytoophidia

The paper uses super-resolution microscopy to show that CTPS forms dynamic, reticular structures called cytoophidia in human cells, which may accommodate other enzymes like IMPDH.

Structural basis of human PRPS2 filaments

This study determines the structure of hPRPS2 polymers using cryo-EM, revealing how ADP binding affects polymerization and catalytic activity.

The trifecta of disease avoidance, silique shattering resistance and flowering period elongation achieved by the BnaIDA editing in Brassica napus

This study edits two IDA homologues in Brassica napus to prevent petal shedding, enhance silique shattering resistance, and extend flowering period, without affecting agronomic traits.

A serotonergic axon-cilium synapse drives nuclear signaling to maintain chromatin accessibility

The paper identifies axo-ciliary synapses that mediate serotonin signaling to regulate chromatin accessibility in hippocampal neurons.

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.

The paper uses cryo-EM and AlphaFold2 to determine the structure of SARS-CoV-2 Nsp2, revealing its zinc-binding site and potential interactions with host proteins.

Discovery of rhodomyrtone as a broad-spectrum antiviral inhibitor with anti-SARS-CoV-2 activity

This paper identifies rhodomyrtone as a broad-spectrum antiviral with activity against SARS-CoV-2 and other viruses, showing potent antiviral effects and low resistance potential.