K. Qiu

Single cell analysis uncovers striking cellular heterogeneity of lung infiltrating Tregs during eosinophilic vs. neutrophilic allergic airway inflammation

The paper uses single-cell RNA sequencing to analyze lung-infiltrating Tregs in eosinophilic and neutrophilic allergic airway inflammation models, revealing significant heterogeneity and tissue-residency differences.

Quantifying cell viability through organelle ratiometric probing

This paper introduces a fluorescent probe, PCV-1, and an analytical assay called organelle ratiometric probing (ORP) to quantify cell viability at the single-cell level using super-resolution microscopy.

Lymphocyte activation gene 3 (Lag3) supports Foxp3+ Treg cell function by restraining c-Myc-dependent aerobic glycolysis

This study shows Lag3 supports Foxp3+ Treg cell function by restraining c-Myc-dependent aerobic glycolysis, which is critical for suppressing autoimmune inflammation.

Enhancing Mitochondrial Functions by Optogenetic Clustering

This paper develops an optogenetic method to control mitochondrial clustering and shows it enhances mitochondrial functions.

Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

Hormone Receptor-status Prediction in Breast Cancer Using Gene Expression Profiles and Their Macroscopic Landscape

This study compares gene expression profiling (GEP) and immunohistochemistry (IHC) for predicting hormone receptor status in breast cancer, finding GEP provides more accurate classification and better prognostic value.