An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts
Y. Guo, S. Shu, Y. Zhou, W. Peng, Z. Jiang, Y. Li, T. Li, F. Du, L. Wang, X. Chen, J. Dong, C. Zhao, M. H. Wang, Y. Sun, H. Sun, , J. Pu
This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.
bioRxiv · Jul 3, 2024 · PreprintMicrobiology