F. Xia

Data Imbalance in Drug Response Prediction - Multi-Objective Optimization Approach in Deep Learning Setting

This paper addresses data imbalance in drug response prediction by introducing a multi-objective optimization approach using a custom loss function to improve model performance.

Related PP2C phosphatases Pic3 and Pic12 negatively regulate immunity in tomato to Pseudomonas syringae

This study identifies Pic3 and Pic12 as PP2C phosphatases that negatively regulate tomato immunity against Pseudomonas syringae through flagellin-independent pathways.

PP2C phosphatase Pic14 negatively regulates tomato Pto/Prf-triggered immunity by inhibiting MAPK activation

This paper identifies Pic14 as a negative regulator of Pto/Prf-triggered immunity in tomato by inhibiting MAPK activation through dephosphorylation of Mkk2.

Dual-targeted nanoparticulate drug delivery systems for enhancing triple-negative breast cancer treatment

This paper develops a dual-targeted nanoparticulate drug delivery system (SJNP) combining SN38 and JQ-1 to enhance triple-negative breast cancer treatment by disrupting DNA repair and mitochondrial function.

Short tandem repeat mutations regulate gene expression in colorectal cancer

This study identifies 1244 expression STRs (eSTRs) in colorectal cancer, showing their association with gene expression and mutability in MSI tumors, suggesting potential therapeutic targets.

SANTA FE OXA: Self-assembled oxaliplatin nanomicelle for enhanced cascade cancer chemotherapy via self-sensitized ferroptosis

This paper develops a nanomicelle, SANTA FE OXA, that enhances cancer chemotherapy by inducing ferroptosis and reducing systemic toxicity.

Simultaneous multimodal three-photon and optical coherence microscopy of the mouse brain in the 1700 nm optical window in vivo

This paper demonstrates a multimodal imaging system combining three-photon microscopy and optical coherence microscopy in vivo for deep brain imaging with high resolution.

Impact of Grain for Green Project on Water Resources and Ecological Water Stress in Yanhe River Basin

This study assesses the impact of the Grain for Green Project on water resources and ecological water stress in the Yanhe River Basin using SWAT modeling and scenario analysis.

Genome-wide in vivo screen of circulating tumor cells identifies SLIT2 as a regulator of metastasis

This study identifies SLIT2 as a regulator of metastasis through a genome-wide CRISPR screen of circulating tumor cells in a mouse model.

Hydrogel-coating improves the in-vivo stability of electrochemical aptamer-based biosensors

This paper demonstrates that hydrogel-coating enhances the in vivo stability of electrochemical aptamer-based biosensors without compromising detection performance.