W. Fang

The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus

This paper identifies a novel penetration ring formed by secreted proteins in the rice blast fungus after cell wall penetration, which persists at the plasma membrane interface during invasion.

TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis

This study shows that TAK1 phosphorylates PLCE1 at S1060, reducing PIP2 hydrolysis and inhibiting esophageal squamous cancer metastasis.

Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance

This study shows that palmitic acid induces mTORC1 activation via Tip60-mediated Rheb acetylation, leading to insulin resistance, while unsaturated fatty acids do not.

A Novel Angiogenesis Role of GLP-1(32-36) to Rescue Diabetic Ischemic Lower Limbs via GLP-1R-Dependent Glycolysis

This study identifies GLP-1(32-36) as a therapeutic agent that rescues diabetic ischemic lower limbs by enhancing glycolysis and EPC function via GLP-1R-dependent mechanisms.

The wheat head blight pathogen Fusarium graminearum recruits facultative endohyphal bacteria from the soil, making the fungal-bacterial holobiont nitrogen-fixing and increasing the fungal pathogenicity

This study shows that the wheat pathogen Fusarium graminearum can acquire nitrogen-fixing facultative endohyphal bacteria from soil, enhancing its pathogenicity.

Rab7/Retromer-based endolysosomal trafficking facilitates effector secretion and host invasion in rice blast

This study identifies a novel endolysosomal trafficking pathway in Magnaporthe oryzae that facilitates effector secretion and host invasion via Rab7/Retromer/MoSnc1-mediated vesicle transport.

The Flowering Repressor SVP recruits the TOPLESS co-repressor to control flowering in chrysanthemum and Arabidopsis

This study shows that SVP interacts with TPL to repress flowering by inhibiting FT gene expression in chrysanthemum and Arabidopsis, highlighting a conserved mechanism across species.

Acoustic and postural displays in a miniature and transparent teleost fish, Danionella dracula

This study identifies acoustic and postural displays in Danionella dracula during aggressive interactions, showing differences based on residency and body size.

Polypeptides IGF-1C and P24 synergistically promote osteogenic differentiation of bone marrow mesenchymal stem cells in vitro through the p38 and JNK signaling pathways

This study shows that IGF-1C and P24 together enhance osteogenic differentiation of BMSCs by activating p38 and JNK pathways.

ZHX2 Promotes HIF1α Oncogenic Signaling in Triple-Negative Breast Cancer

This study identifies ZHX2 as a promoter of HIF1α oncogenic signaling in TNBC, showing its role in cell growth, invasion, and metastasis through interaction with HIF1.

Sequence Determinants of Human Junctophilin-2 Protein Nuclear Localization and Phase Separation

This study identifies nuclear localization signals and phase separation properties of human JPH2, revealing its ability to form liquid droplets and amyloid-like aggregates in the nucleus.

SNHG16 promotes cell proliferation and inhibits cell apoptosis via regulation of the miR-1303p/STARD9 axis in renal cell carcinoma

This study identifies SNHG16 as a promoter of renal cell carcinoma proliferation and inhibitor of apoptosis through the miR-1301-3p/STARD9 axis.

The nonstructural protein 5 of coronaviruses antagonizes GSDMD-mediated pyroptosis by cleaving and inactivating its pore-forming p30 fragment

This study identifies how coronavirus Nsp5 protein inhibits pyroptosis by cleaving GSDMD, preventing pore formation and viral replication inhibition.

Pan-genome analyses of peach and its wild relatives provide insights into the genetics of disease resistance and species adaptation

The paper performs pan-genome analysis of peach and its wild relatives to identify genetic variations related to disease resistance and high-altitude adaptation.

Evolutionary conserved multifunctional nitric oxide synthesis proteins responding to bacterial MAMPs are located at the endoplasmic reticulum

The paper identifies an evolutionary conserved NO-producing system in fungi, mammals, and plants, revealing multifunctional enzymes with implications for agriculture and medicine.

Targeting a critical step in fungal hexosamine biosynthesis

This study identifies Gna1 as an antifungal target in Aspergillus fumigatus by showing its essential role in cell wall synthesis and demonstrating a chemical inhibitor.

Identification of pathogens in culture-negative infective endocarditis with metagenomic analysis

This study uses metagenomic sequencing to identify pathogens in culture-negative infective endocarditis cases, providing antimicrobial resistance profiles without culturing.