X. Dou

S2' cleavage site plays a decisive role in expansion of Vero cell tropism by infectious bronchitis virus HV80, with Q855H promoting cell-to-cell fusion

This study identifies the S2' cleavage site and Q855H mutation as critical for HV80's Vero cell tropism and cell-to-cell fusion.

Senescent cells develop PDK4-dependent hypercatabolism and form an acidic microenvironment to drive cancer resistance

This study identifies PDK4-dependent hypercatabolism in senescent cells that creates an acidic microenvironment, promoting cancer resistance and age-related pathologies.

Whole genome regulatory effect of MoISW2 and consequences for the evolution of rice plant pathogenic fungus Magnaporthe oryzae

The paper investigates the regulatory role of MoISW2 in Magnaporthe oryzae, showing its impact on gene expression variability and niche-determinant genes, with implications for fungal evolution.

Nuclear m6A reader Ythdc1 regulates the scaffold function of LINE1 in mouse ESCs

This study shows Ythdc1, an m6A reader, regulates LINE1 scaffold function in mouse ESCs, affecting self-renewal and differentiation through chromatin interactions.

Senescent stromal cells promote cancer resistance through SIRT1 loss-potentiated overproduction of small extracellular vesicles

This study shows senescent stromal cells release sEVs that promote cancer drug resistance via SIRT1 loss, and suggests targeting SIRT1 could prevent this resistance.