J. Liang

This paper develops barcoding proteins to enable highly multiplexed imaging of biosensors in live cells by computationally unmixing signals from different biosensors.

This paper develops a nanobody agonist that activates the Hedgehog pathway by stabilizing an alternative conformation of Patched1, disrupting its sterol conduit and providing a new approach for transporter-related drug development.

This study identifies Il13 enhancers that mediate gene transcription in response to antigenic stimulation by analyzing histone modifications and transcription factor binding sites.

This study shows that ACE2 is a target of the γ-secretase complex, leading to the release of a soluble C-terminal fragment and altered trafficking of ACE2.

This paper develops a potent synthetic nanobody that neutralizes SARS-CoV-2 by locking its Spike protein in an inactive conformation, enabling aerosol delivery as a prophylactic or therapeutic agent.

The paper identifies a zinc metabolic defect in alveolar progenitor cells in IPF and aged mice, linked to impaired renewal and fibrosis through ZIP8 downregulation.

This study identifies metabolic defects in alveolar progenitor cells during aging and lung injury that impair their renewal capacity.

This study identifies fibroblast subpopulations in mouse and human lungs using scRNA-seq, revealing conserved transcriptomic signatures and their roles in fibrosis.

This study reveals that Smoothened (SMO) activates GLI transcription factors by sequestering PKA catalytic subunits at the membrane, bypassing traditional GPCR signaling mechanisms.

The paper shows that pan-resistant Candida auris strains from a New York outbreak are susceptible to antifungal combinations, despite having mutations in multiple drug targets.

This study uses CT and PET/CT imaging to quantify SARS-CoV-2-induced lung abnormalities in crab-eating macaques, providing an objective endpoint for evaluating medical countermeasures.

This study develops an integrated platform to rapidly discover and validate potent antiviral human monoclonal antibodies against Zika virus.

This study uses human liver organoids to show SARS-CoV-2 infects cholangiocytes, disrupts bile transport, and causes liver damage, suggesting targeting viral effects on the liver could improve COVID-19 treatment.

This study shows that the fibrinolytic niche regulates alveolar type 2 cell function and regeneration through the uPA-A6-CD44-ENaC cascade, with implications for lung injury repair.

The paper shows that siderophores trigger extracellular superoxide production in carbon-starved Arthrobacter strains when carbon sources recover, and highlights interference of DTPA in superoxide quantification.

This study shows that neuronal lipolysis prevents lipid droplet accumulation and alleviates neurodegeneration in C. elegans by regulating PUFA partitioning and phospholipid incorporation.

This study models the relationship between seasonal climate variability and dengue incidence in Hong Kong, finding that pre-summer rainfall negatively correlates with annual incidence while temperature positively correlates.

The paper identifies a p53-dependent process called mintosis that eliminates aneuploid mitotic progenies through entosis to counteract genome instability.

This study identifies IRAK1-mediated supramolecular organizing centers that coordinate multiple immune pathways to license inflammasome activation in response to microbial signals.

This study identifies cytogenetic errors in hybrid male sterility of Anopheles gambiae complex mosquitoes, showing premeiotic arrest and meiotic division failure in reciprocal crosses.

This paper presents a deep learning framework for designing and quantifying point-of-care sensors, demonstrating a paper-based VFA for high-sensitivity hsCRP testing with competitive accuracy and hook-effect mitigation.

This study develops GeTFEP, a transfer free energy profile for transmembrane proteins, showing its ability to predict membrane positioning, orientation, and important residue sites.

This study differentiates dermal mesenchymal stem cells into vascular endothelial cells using endothelial cell line conditioned medium, showing high CD31 expression and angiogenic ability.

This study shows that inhaled nicotine during pregnancy disrupts systemic and uterine hemodynamics and causes cardiac arrhythmia in rats, with effects blocked by a nicotinic receptor antagonist.