D. Cao

Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer

The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.

The cGAS-STING Pathway Is Essential in Acute Ischemia-Induced Neutropoiesis and Neutrophil Priming in the Bone Marrow

This study shows that the cGAS-STING pathway is essential for neutrophil production and function in the bone marrow during acute myocardial ischemia, promoting myocardial repair.

Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells

This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.

Stimulation Effects Mapping for Optimizing Coil Placement for Transcranial Magnetic Stimulation

This paper introduces a framework for optimal TMS coil placement without segmentation or meshing, validated across multiple datasets showing consistent results.

The receptor VLDLR binds East Equine Encephalitis virus through multiple distinct modes

This study identifies VLDLR as an EEEV receptor and characterizes its binding modes through cryo-EM and biochemical analyses, revealing mutations that enhance viral attachment.

Auxin-independent effects of apical dominance induce temporal changes in phytohormones

This study investigates the role of auxin and other phytohormones in apical dominance, showing that auxin's effects on cytokinins are significant after bud release, while strigolactones have limited impact on initial bud outgrowth.

Temporal integration of rod signals in luminance and chromatic pathways

The paper investigates how rod signals influence reaction times in luminance and chromatic pathways using a four-primary display.

Is Melanopsin Activation Affecting Large Field Color Matching Functions?

The paper investigates whether melanopsin activation explains differences in large field versus foveal color matching functions, finding evidence supporting its role in Large Field S Fundamentals.

Comparing flickering and pulsed chromatic pupil light responses

This study compares flickering and pulsed chromatic pupil light responses to validate the flickering paradigm.

Supramolecular assembly of chloroplast NAD(P)H dehydrogenase-like complex with photosystem I from Arabidopsis thaliana

The paper reports the 3.9 Å resolution structure of the Arabidopsis thaliana NDH-PSI supercomplex, revealing its assembly and interactions.

METTL9 regulates N1-histidine methylation of zinc transporters to promote tumor growth

This study identifies METTL9 as a tumor-promoting methyltransferase that methylates zinc transporters, disrupting zinc homeostasis and promoting cancer growth.

HEXOKINASE1 interferes with cytokinin synthesis and strigolactone perception during sugar-induced shoot branching

This study shows that HEXOKINASE1 regulates shoot branching by interacting with cytokinin synthesis and strigolactone perception in response to sugars.

Structural basis for the inhibition of the papain-like protease of SARS-CoV-2 by small molecules

The paper identifies GRL0617 as a non-covalent inhibitor of SARS-CoV-2 PLpro with an IC50 of 2.1 μM, supported by co-crystal and NMR data showing its mechanism of action.

Therapy-induced transdifferentiation promotes glioma growth independent of EGFR signaling

This study identifies therapy-induced transdifferentiation as a mechanism of EGFR-targeted therapy resistance in gliomas, independent of EGFR signaling, and suggests combinatorial therapies targeting both EGFR and transdifferentiation pathways.

Transgenerational inheritance of abnormal spermatogenesis with Igf2/H19 epigenetic alteration in CD1 mouse induced by in utero arsenic exposure

This study shows that prenatal arsenic exposure in mice leads to transgenerational impairments in spermatogenesis, associated with epigenetic changes in Igf2 and H19.

Revealing cellular heterogeneity and in vitro differentiation trajectory of cultured human endometrial mesenchymal-like stem cells using single-cell RNA sequencing