D. Wen

Multiomic Screening Unravels the Immunometabolic Signatures and Drug Targets of Age-Related Macular Degeneration

This study uses multiomic methods to identify immunometabolic pathways and drug targets in AMD, highlighting key genes and pathways involved in disease progression and potential therapeutic interventions.

Biocompatible Neodymium-Doped Nanocrystals as Probes for Diffraction-limited, in vitro Temperature Sensing

This paper develops neodymium-doped nanocrystals for diffraction-limited, in vitro temperature sensing with high sensitivity and biocompatibility in cancer cells.

Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats

This study develops a CKD-PH rat model through 5/6 nephrectomy and high-salt diet, showing increased Ang II and RAAS imbalance, ACE2 downregulation, and metabolic changes linked to pulmonary hypertension.

Combining Bulk and Single-Cell RNA Sequencing Data to Identify RNA methylation and Autophagy-Related Signatures in Patients with Chronic Obstructive Pulmonary Disease

The paper identifies RNA methylation and autophagy-related genes in COPD using bulk and single-cell RNA sequencing data and validates them in animal models.

Elevated concentration and nitrogen addition affects responses of foliar phosphorus fractions in invasive species to increased phosphorus supply

The paper examines how elevated CO2 and nitrogen addition influence foliar phosphorus fractions in invasive and native species under varying phosphorus supplies.

The glycine locating at random coil of picornaviruses VP3 enhances viral pathogenicity by targeting p53 to promote apoptosis and autophagy

This study shows that the Gly129 residue in FMDV-VP3 enhances viral pathogenicity by promoting apoptosis and autophagy through p53 interaction, and this residue is conserved across picornaviruses.

Long noncoding RNAs sustain high expression of exogenous Oct4 by sponging miRNA during reprogramming

The paper shows lncRNAs and circRNAs sponge miRNAs to maintain Oct4 expression during reprogramming, enhancing reprogramming efficiency.

Inferring Phylogenetic Networks Using PhyloNet

The paper describes the evolution and features of PhyloNet, a software package for inferring phylogenetic networks from genetic data.

Bayesian Inference Of Phylogenetic Networks From Bi-allelic Genetic Markers

This paper introduces a Bayesian method for inferring phylogenetic networks from bi-allelic markers, demonstrating good accuracy and robustness on simulated and empirical data.

Co-estimating Reticulate Phylogenies and Gene Trees from Multi-locus Sequence Data

This paper introduces a Bayesian method to co-estimate species phylogenies and gene trees from multi-locus sequence data, accounting for reticulation and incomplete lineage sorting.