Author

X.-W. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

B. T. Emmer· 2 shared B. Xu· 2 shared C. Wang· 2 shared D. Ginsburg· 2 shared H. Fang· 2 shared V. T. Tang· 2 shared X. Li· 2 shared Y. Wang· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersPhysiology

B. T. Emmer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A Host-Harbored Metabolic Susceptibility of Coronavirus Enables Broad-Spectrum Targeting

H. Fang, Y. Wang, L. Liu, K. Cheng, P. Li, Y. Tan, X. Hao, M. Mei, X. Xu, Y. Yao, F. Zan, L. Wu, Y. Zhu, B. Xu, D. Huang, , X.-W. Chen

The paper identifies a host metabolic pathway essential for coronavirus replication and shows that inhibiting it with Propranolol has broad antiviral effects.

bioRxiv · Dec 7, 2022 · PreprintCell Biology

Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol

V. T. Tang, J. McCormick, B. Xu, Y. Wang, H. Fang, X. Wang, D. Siemieniak, R. Khoriaty, B. T. Emmer, X.-W. Chen, D. Ginsburg

This study shows that reducing SURF4 in the liver decreases PCSK9 and increases LDLR, leading to lower plasma cholesterol despite reduced lipoprotein secretion.

bioRxiv · Aug 1, 2022Physiology

SARS-CoV-2-Triggered Mast Cell Rapid Degranulation Induces Alveolar Epithelial Inflammation and Lung Injury

M.-L. Wu, F.-L. Liu, J. Sun, X. Li, X.-Y. He, H.-Y. Zheng, R.-J. Pei, H. Sun, Y.-H. Zhou, Q.-H. Yan, C.-X. Wu, L. Chen, G.-Y. Yu, J. Chang, X. Jin, , J.-H. Wang

This paper shows that SARS-CoV-2 triggers mast cell degranulation, leading to alveolar epithelial inflammation and lung injury, and that MC stabilizers can reduce these effects.

bioRxiv · Jun 24, 2021Microbiology

The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9

B. T. Emmer, G. G. Hesketh, E. Kotnik, V. T. Tang, P. J. Lascuna, J. Xiang, A.-C. Gingras, X.-W. Chen, D. Ginsburg

This study identifies SURF4 as a cargo receptor that facilitates PCSK9 secretion by linking it to COPII components and confirming its functional role through multiple experimental approaches.

bioRxiv · May 31, 2018Cell Biology

Base-resolution mapping reveals distinct m1A methylome in nuclear- and mitochondrial-encoded transcripts

X. Li, X. Xiong, M. Zhang, K. Wang, Y. Chen, J. Zhou, Y. Mao, J. Lv, D. Yi, X.-W. Chen, C. Wang, S.-B. Qian, C. Yi

The paper develops a base-resolution m1A profiling method and identifies distinct m1A methylome classes in human nuclear and mitochondrial transcripts, showing functional roles in translation efficiency and mitochondrial mRNA regulation.

bioRxiv · Oct 13, 2017Biochemistry