J. Lv

FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage

This study shows FLASH irradiation increases cytochrome c leakage from mitochondria in normal cells, reducing mtDNA accumulation and IFN-β secretion, while having the opposite effect in cancer cells.

Large-scale statistical mapping of T-cell receptor β sequences to Human Leukocyte Antigens

The paper maps T-cell receptor β sequences to specific HLA allotypes using population-level TCR repertoire data, enabling accurate HLA imputation and revealing insights into TCR-HLA interactions.

Transdifferentiation of fibroblasts into muscle cells to constitute cultured meat with tunable intramuscular fat deposition

This study transdifferentiates chicken fibroblasts into muscle cells with tunable fat deposition to create cultured meat mimics with controllable intramuscular fat content.

M1 Macrophage-Related Genes Model for NSCLC Immunotherapy Response Prediction

This study develops a model using M1 macrophage-related genes to predict immunotherapy response and prognosis in advanced NSCLC patients.

High red/far-red ratio promotes root colonization of Serratia plymuthica A21-4 in tomato by root exudates-stimulated chemotaxis and biofilm formation

Alteration of pro-carcinogenic gut microbiota is associated with clear cell renal cell carcinoma tumorigenesis

This study identifies associations between gut microbiota composition and serum metabolites with clear cell renal cell carcinoma, suggesting potential risk factors for tumorigenesis.

A host E3 ubiquitin ligase regulates Salmonella virulence by targeting an SPI-2 effector involved in SIF biogenesis

The paper identifies TRIM32 as a host E3 ubiquitin ligase that targets SseK3, an SPI-2 effector, to restrict Salmonella-induced filament biogenesis and replication.

Regulation of pDC Fate Determination by Histone Deacetylase 3

This study shows HDAC3 is essential for pDC development and hematopoietic progenitor homeostasis, with HDAC3 repressing cDC1-associated genes to promote pDC differentiation.

Highly efficient multiplex genome editing in dicot plants using improved CRISPR/Cas systems

This study improves CRISPR/Cas9 systems for efficient gene editing in dicot plants, achieving over 80% homozygous/bi-allelic mutations in tobacco and tomato.

Oxalic acid binds to gustatory receptor Gr23a and inhibits feeding in the brown planthopper

The paper identifies oxalic acid as a ligand for the brown planthopper's gustatory receptor Gr23a, showing it inhibits feeding and is sensed by the receptor.

ASFV pD345L protein negatively regulates NF-kB signaling through inhibiting IKK kinase activity

This study identifies pD345L as an ASFV protein that inhibits NF-κB signaling by blocking IKK kinase activity, providing insights into ASFV immune evasion mechanisms.

Prediction of occult tumor progression via platelet RNAs in a mouse melanoma model: a potential new platform of cancer screening for early detection of cancer

This paper identifies platelet RNAs that predict occult tumor progression in a mouse melanoma model, showing high diagnostic accuracy for early cancer detection.

FOD-Net: A Deep Learning Method for Fiber Orientation Distribution Angular Super Resolution

FOD-Net improves angular resolution of FOD images from clinical dMRI data to match research-quality data, enabling better tractography and connectome reconstruction.

Species-resolved sequencing of low-biomass microbiomes by 2bRAD-M

This paper introduces 2bRAD-M, a low-cost metagenome-sequencing method that enables species-level microbial profiling of low-biomass and degraded samples with high accuracy.

Assessment of the optimum fertilizer rates and planting density for soybean production in China

The paper evaluates optimal fertilizer rates and planting density for soybean production in China using field experimental data, finding varying optimal rates for spring and summer soybean.

3D association of ER, PR and Her2 at protein levels to aid sub-grouping of breast cancer patients in routine clinical practice

This study uses Quantitative Dot Blot to measure protein levels of ER, PR, and Her2 in FFPE samples, enabling 3D subtyping of breast cancer patients for prognosis and prediction.

Developing a routine lab test for absolute quantification of Her2 in Formalin Fixed Paraffin Embedded (FFPE) breast cancer tissues using Quantitative Dot Blot (QDB) method

This paper develops and validates a Quantitative Dot Blot (QDB) method for absolute quantification of Her2 in FFPE breast cancer tissues, showing high correlation and diagnostic accuracy comparable to IHC and FISH.

Hv1 channel supports insulin secretion in pancreatic β cells through calcium entry, depolarization and intracellular pH regulation

Apigenin relaxes rat intrarenal arteries: involvement of Cl- channels and K+ channels

This study shows apigenin relaxes rat intrarenal arteries by modulating Cl- and K+ channels, with effects mediated through CaCCs and Kv channels.

Base-resolution mapping reveals distinct m1A methylome in nuclear- and mitochondrial-encoded transcripts

The paper develops a base-resolution m1A profiling method and identifies distinct m1A methylome classes in human nuclear and mitochondrial transcripts, showing functional roles in translation efficiency and mitochondrial mRNA regulation.