Z. Bian

Bola-amphiphilic dendrimer empowers imatinib to target metastatic ovarian cancer stem cells via beta-catenin-HRP2 signaling axis

This study develops a nanoformulation Bola/IM to target metastatic ovarian cancer stem cells via the beta-catenin-HRP2 signaling axis, showing improved efficacy and synergy with cisplatin.

Notch-1 mediates Epithelial-Mucosal Healing during Murine Colitis Recovery Phase

This study investigates the role of Notch-1 signaling in colonic epithelial healing during colitis recovery in mice, finding that its deletion impairs mucosal repair.

SIRPα sequesters SHP-2 to promote IL-4/13 signaling and alternative activation of macrophages

This study shows SIRPα enhances IL-4/13 signaling in macrophages by sequestering SHP-2, promoting alternative activation and immunosuppression.

High-throughput functional characterization of visceral afferents by optical recordings from thoracolumbar and lumbosacral dorsal root ganglions

The paper develops a cost-effective microscopy system for high-throughput optical recordings of visceral afferent activity in mouse dorsal root ganglia.

Immune Response Drives Outcomes in Prostate Cancer: Implications for Immunotherapy

This study identifies an immune class in prostate cancer associated with better recurrence-free survival and response to anti-PD-1/PD-L1 immunotherapy.

A Clostridia-rich microbiota contributes to increased excretion of bile acids in diarrhea-predominant irritable bowel syndrome

This study identifies a Clostridia-rich microbiota as a contributor to excessive bile acid excretion in IBS-D patients through metagenomic and metabolomic analyses.