W. Ren

High-speed Auto-Polarization Synchronization Modulation Three-dimensional Structured Illumination Microscopy

This paper introduces a high-speed 3DSIM system using DMD and electro-optic modulators, achieving improved resolution and imaging speed for various biological specimens.

Characterization of Pro-Fibrotic Signaling Pathways using Human Hepatic Organoids

This study uses human hepatic organoids to identify pro-fibrotic signaling pathways and potential therapies for liver fibrosis.

Integrin beta4 promotes DNA damage drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/Rac1

This study identifies the Integrin β4/TNFAIP2/IQGAP1/RAC1 pathway as a mechanism for DNA damage drug resistance in triple-negative breast cancer.

Visualization of mitochondrial cristae and mtDNA evolvement and interactions with super-resolution microscopy

This study uses super-resolution microscopy to visualize mitochondrial cristae and mtDNA interactions, revealing their dynamic relationship and distribution patterns under different cellular conditions.

Monitoring mouse brain perfusion with hybrid magnetic resonance optoacoustic tomography

This paper develops a hybrid magnetic resonance and optoacoustic tomography system for mouse brain imaging and demonstrates its ability to capture complementary anatomical and contrast agent dynamics.

An mTOR-independent Macroautophagy Activator Ameliorates Tauopathy and Prionopathy Neurodegeneration Phenotypes

The paper identifies CCT020312, an mTOR-independent autophagy activator, which reduces tauopathy and prionopathy neurodegeneration phenotypes by enhancing autophagy flux and clearing protein aggregates.

Novel leaf-root coordination driven by leaf water storage tissues in mangroves

This study identifies a unique leaf-root coordination mechanism in mangroves driven by leaf water storage tissues, distinct from non-mangrove plants.

The Statistical Trends of Protein Evolution: A Lesson from AlphaFold Database

This study analyzes AlphaFold-predicted protein structures across organisms to show that higher complexity correlates with specific structural and dynamic properties and statistical structural proximity reflecting phylogenetic relationships.

Characterization of SARS-CoV-2 variants B.1.617.1 (Kappa), B.1.617.2 (Delta) and B.1.618 on cell entry, host range, and sensitivity to convalescent plasma and ACE2 decoy receptor

This study characterizes SARS-CoV-2 variants Kappa, Delta, and B.1.618, finding increased ACE2 binding in non-human hosts, enhanced spike cleavage, and reduced neutralization sensitivity, but maintained sensitivity to ACE2 decoy receptor.

Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption

This study identifies the Y453F mutation in SARS-CoV-2 spike protein as enhancing binding to mink ACE2 while maintaining human ACE2 utilization, highlighting its role in host adaptation.

Susceptibilities of human ACE2 genetic variants in coronavirus infection

The paper investigates how genetic variants in the ACE2 gene affect susceptibility to SARS-CoV-2 infection by analyzing their impact on viral entry.

A cell type-specific multiomics uncovers a guard cell-specific RAF15-SnRK2.6/OST1 kinase cascade

The paper develops a cell type-specific multiomics pipeline to analyze guard cells and mesophyll cells, revealing a kinase cascade involved in ABA-induced stomatal closure.

Phase separation of RNA-binding protein promotes polymerase engagement and transcription

The paper investigates how RNA-binding proteins (RBPs) influence RNA polymerase II activity through phase separation, showing that RBPs like PSPC1 enhance polymerase engagement and transcription.

Next generation of anti-PD-L1 Atezolizumab with better anti-tumor efficacy in vivo

This paper describes the development of a modified Atezolizumab (Maxatezo) with improved anti-tumor efficacy and reduced anti-drug antibody formation in vivo.

SARS-CoV-2 variants resist antibody neutralization and broaden host ACE2 usage

This study evaluates antibody resistance and ACE2 usage in SARS-CoV-2 variants, finding SA501Y.V2 shows the highest resistance and expanded host range.

A novel cell culture system modeling the SARS-CoV-2 life cycle

This paper develops a BSL-2 cell culture system for producing SARS-CoV-2 virus-like particles to enable safe antiviral screening and life cycle studies.

Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry

The paper identifies species-specific genetic differences in ACE2 that determine SARS-CoV-2 entry capability and shows that humanizing these residues in koala and mouse ACE2 enables viral entry.

Functional and Genetic Analysis of Viral Receptor ACE2 Orthologs Reveals a Broad Potential Host Range of SARS-CoV-2

This study identifies ACE2 orthologs from diverse species that can support SARS-CoV-2 entry, suggesting a broad host range for the virus.

Recombinant SARS-CoV-2 spike S1-Fc fusion protein induced high levels of neutralizing responses in nonhuman primates

This study shows that a recombinant SARS-CoV-2 S1-Fc fusion protein induces strong neutralizing antibodies in nonhuman primates and can be produced at scale for vaccine development.

Morphological and physiological response strategies of Vallisneria natans at different water depths and light conditions

This study investigates how water depth and light conditions affect the morphology, physiology, and resource allocation of Vallisneria natans, showing shifts in resource allocation between light acquisition and reproduction.

Substrate deformation regulates DRM2-mediated DNA methylation in plants

This study identifies DNA deformation as a mechanism regulating DRM2-mediated methylation specificity in plants, showing how substrate deformation influences substrate preference.

Admistration of Exogenous Melatonin Improves the Diurnal Rhythms of Gut Microbiota in High Fat Diet-Fed Mice

This study shows that exogenous melatonin administration restores diurnal rhythms in gut microbiota and host metabolism in high fat diet-fed mice.

Essentiality of CREBBP in EP300 truncated B-cell lymphoma revealed by genome-wide CRISPR-Cas9 screen

The paper identifies CREBBP dependency in a DLBCL cell line with EP300 truncation using CRISPR-Cas9 screens and genomic data, suggesting therapeutic targets for heterogeneous cancers.

Contraction of the ROS scavenging enzyme glutathione S-transferase gene family in cetaceans

This study examines the evolution of the glutathione S-transferase gene family in cetaceans, finding lineage-specific gene losses and positive selection, suggesting adaptation to aquatic environments.

Comparative genomics reveals contraction in cytosolic glutathione transferase genes in cetaceans: implications for oxidative stress adaptation

This study investigates the molecular evolution of glutathione transferase (GST) genes in cetaceans, finding gene loss and adaptive evolution linked to oxidative stress adaptation.

Variation and diversification of the microbiome of Schlechtendalia chinensis on two alternate host plants

This study compares the microbiome of Schlechtendalia chinensis aphids on two host plants, finding distinct bacterial communities associated with each host.

Dorsal Hippocampal Activation Suppresses Neuropathic Pain Behaviors: Chronic pain as extinction-resistant pain-related memory traces

This study shows that activating the dorsal hippocampus reduces neuropathic pain behaviors through specific neural circuits.