Z. Lei

Single-cell RNA sequencing reveals recruitment of the M2-like CCL8high macrophages in Lewis lung carcinoma-bearing mice following hypofractionated radiotherapy

This study uses single-cell RNA sequencing to show hypofractionated radiotherapy recruits CCL8high macrophages, reprograms them to an immunosuppressive state, and enhances tumor growth, which can be counteracted by CCL inhibitor Bindarit.

Universal protection against SARS-CoV-2 viruses by multivalent mRNA vaccine in mice

This study evaluates a multivalent mRNA vaccine against SARS-CoV-2 variants in mice, showing broad protection against multiple strains.

Poly(A) tail length regulation by mRNA deadenylases is critical for suppression of transposable elements

This study shows that RNA deadenylation by the CCR4-NOT complex is critical for suppressing transposable elements in Arabidopsis, independent of small RNA targeting.

The Gene Knockout of Angiotensin II Type 1a Receptor Improves High-fat Diet-Induced Obesity in rat via Promoting Adipose Lipolysis

This study shows that knocking out the Angiotensin II Type 1a Receptor in rats reduces high-fat diet-induced obesity by enhancing adipose lipolysis through the cAMP/PKA pathway.

Suppression of transposon mobilization by m6A-mediated RNA sequestration in stress granules

This study shows that m6A RNA methylation sequesters transposon RNA in stress granules, preventing mobilization, and that demethylation by AtALKBH9B allows transposon activation.

Efficient and Explainable Deep Neural Networks for Airway Symptom Detection in Support of Wearable Health Technology

This study develops efficient and explainable DNNs for detecting airway symptoms using mechanoacoustic data, achieving 83.7% accuracy with a low memory footprint.

Differential Interactions Between Human ACE2 and Spike RBD of SARS-CoV-2 Variants of Concern

This study uses molecular dynamics and experiments to analyze how mutations in SARS-CoV-2 variants affect their binding to ACE2, identifying which variants are more contagious.

Substitutions and codon usage in SARS-CoV-2 in mammals indicate natural selection and host adaptation

This study analyzes SARS-CoV-2 substitutions and codon usage in humans and animals, finding higher substitution rates and adaptation in mink compared to other species.

A Mycobacterium tuberculosis effector protein attacks host innate immunity by acting as an unusual ubiquitinating enzyme

This paper shows that Mtb PknG acts as an unusual ubiquitinating enzyme by promoting ubiquitination of TRAF2 and TAK1 to suppress host innate immunity.

Integrated metabolome and transcriptome analyses provide insight into colon cancer development by the gut microbiota

The paper uses multi-omics analyses to show how gut microbiota influence metabolome and transcriptome changes linked to colon cancer susceptibility in rats.

Translational inhibition and phase separation primes the epigenetic silencing of transposons

The paper shows that ribosome stalling and phase separation are critical for transposon RNA processing and epigenetic silencing in plants.

New mechanism-based inhibitors of aspartate transcarbamoylase for anticancer drug development

This study identifies new ATCase inhibitors by targeting a previously unknown regulatory region and active site, showing strong anticancer effects in cell lines and xenograft models.