Author

P. Ge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Microbiology· 2 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:cryo-EM· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:protein structure prediction· 4 Approach:microscopy & imaging analysis· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. R. Boyer· 3 shared D. S. Eisenberg· 3 shared M. R. Sawaya· 3 shared J. Su· 2 shared M. Liu· 2 shared Q. Cao· 2 shared Y. Li· 2 shared A. Shin· 1 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiochemistry

D. R. Boyer

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Atomic model of Vesicular Stomatitis Virus and Mechanism of Assembly

K. Zhou, Z. Si, P. Ge, J. Tsao, M. Luo, H. Zhou

The paper determines the in situ atomic structures of VSV components using cryoEM and sub-particle reconstruction, revealing their assembly mechanism through interactions.

bioRxiv · May 2, 2022 · PreprintBiochemistry

A subset of Memory B-derived antibody repertoire from 3-dose vaccinees is ultrapotent against diverse and highly transmissible SARS-CoV-2 variants, including Omicron

K. Wang, Z. Jia, L. Bao, L. Wang, L. Cao, H. Chi, Y. Hu, Q. Li, Y. Jiang, Q. Zhu, Y. Deng, P. Liu, N. Wang, L. Wang, M. Liu, , X. Wang

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

bioRxiv · Dec 24, 2021Microbiology

Single molecule tracking of AMPA receptors shows the role of synaptic insertion during maintenance of chemical LTP

C. Jin, S.-S. Ja, P. Ge, H. J. Chun, P. R. Selvin

The paper uses single-molecule tracking to show that synaptic insertion, not lateral diffusion, contributes to maintaining chemical LTP by increasing AMPA receptor subunits at synapses.

bioRxiv · Feb 4, 2021 · PreprintBiophysics

A Mycobacterium tuberculosis effector protein attacks host innate immunity by acting as an unusual ubiquitinating enzyme

J. Wang, P. Ge, Z. Lei, L. Qiang, Q. Chai, Y. Zhang, Z. Lu, D. Zhao, B. Li, J. Su, R. Peng, Y. Pang, Y. Shi, G. F. Gao, X.-B. Qiu, C. H. Liu

This paper shows that Mtb PknG acts as an unusual ubiquitinating enzyme by promoting ubiquitination of TRAF2 and TAK1 to suppress host innate immunity.

bioRxiv · Nov 5, 2020 · PreprintMicrobiology

Cross-neutralization antibodies against SARS-CoV-2 and RBD mutations from convalescent patient antibody libraries

Y. Lou, W. Zhao, H. Wei, M. Chu, R. Chao, H. Yao, J. Su, Y. Li, X. Li, Y. Cao, Y. Feng, P. Wang, Y. Xia, Y. Shang, F. Li, , M. Liu

bioRxiv · Jun 6, 2020 · PreprintImmunology

CryoEM reveals how the small molecule EGCG binds to AD brain-derived tau fibrils and initiates fibril disaggregation

P. M. Seidler, D. R. Boyer, M. R. Sawaya, P. Ge, A. Shin, M. A. DeTure, D. W. Dickson, L. Jiang, D. S. Eisenberg

This study uses cryoEM to determine how EGCG binds to AD tau fibrils and initiates their disaggregation by wedging into a cleft and causing charge repulsions.

bioRxiv · May 29, 2020 · PreprintBiochemistry

Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils

Q. Cao, D. R. Boyer, M. R. Sawaya, P. Ge, D. S. Eisenberg

This study determines the cryo-EM structure of human IAPP fibrils and designs inhibitors to delay aggregation, offering insights into T2D pathology and therapeutic strategies.

bioRxiv · May 25, 2020Biochemistry

Cryo-EM Structures of Four Polymorphic TDP-43 Amyloid Cores

Q. Cao, D. R. Boyer, M. R. Sawaya, P. Ge, D. S. Eisenberg

This study determines the cryo-EM structures of four polymorphic TDP-43 amyloid cores, revealing structural features that distinguish reversible from irreversible aggregation and how a mutation may enhance pathology.

bioRxiv · Apr 6, 2019Biochemistry