Y. Ling

Deficiency in ribosome biogenesis causes streptomycin resistance and impairs motility in Salmonella

This study identifies RimP as a ribosome assembly factor in Salmonella that contributes to streptomycin resistance and motility impairment.

Spatial transcriptome profiling of in vitro 3D tumouroids to study tumour-stroma interactions

This study uses spatial transcriptomics to analyze how different stromal cells affect gene expression and behavior in engineered ameloblastoma tumouroids.

Control of Leaf Width by the APC/CTAD1-WL1-NAL1 Pathway in Rice

This study identifies the APC/CTAD1-WL1-NAL1 pathway as a regulator of leaf width in rice and shows that mutations in WL1 lead to leaf width variation.

A non-coding A-to-T Kozak site change related to the transmissibility of Alpha, Delta and Omicron VOCs

This study identifies two non-coding A-to-T mutations at the Kozak site of the N gene as potentially contributing to the transmissibility of Alpha, Delta, and Omicron SARS-CoV-2 variants.

Unbalanced dietary patterns contribute to the pathogenesis of precocious puberty by affecting gut microbiota and host metabolites

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.

An interactive viral genome evolution network analysis system enabling rapid large-scale molecular tracing of SARS-CoV-2

This paper introduces VENAS, a system for analyzing SARS-CoV-2 genome evolution networks, enabling rapid processing and visualization of large datasets to trace viral mutations and transmission.

Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein

This paper develops a CRISPR-Cas13b-based tool to specifically demethylate m6A modifications on target mRNAs, enhancing their stability and demonstrating efficient gene regulation with minimal off-target effects.

Treatment of Murine Lupus with TIGIT-Ig

This study shows that TIGIT-Ig treatment delays lupus onset, reduces autoantibodies, and improves survival in mice, suggesting potential for human autoimmune disease therapy.