T. Xia

CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis

This study identifies CD81+ senescent fibroblasts as key drivers of inflammation in periodontitis through the C3/C3aR1 axis and shows that senolytics and metformin can reduce inflammation and bone loss.

Hydrophobic bulk conservation and genetic code determine the pattern of prokaryotic genome organization

The paper analyzes prokaryotic genome organization patterns and finds that GC-content, mutational biases, and genetic code influence GC-skew, AT-skew, and gene strand bias through synonymous and nonsynonymous substitutions.

Potential clinical value and influence of conductivity in conductive cardiac patches for reducing post-MI arrythmia risks

This study evaluates the clinical value of conductive cardiac patches by testing different conductivities and shows that higher conductivity reduces arrhythmia risks in post-MI hearts.

Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs

This study shows that sustained store-operated calcium entry (SOCE) and chromatin accessibility in iTregs lead to phenotypical instability, unlike tTregs.

FoxP3-mediated blockage of ryanodine receptor 2 is the molecular basis for the contact-based suppression by regulatory T cells

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

Identification and calibration of ultrabright localizations to eliminate quantification error in SMLM

This paper identifies and calibrates ultrabright localizations in SMLM to improve quantification accuracy for biomolecular organization.

The genomics and physiology of abiotic stressors associated with global elevation gradients in Arabidopsis thaliana

This study investigates elevational adaptation in Arabidopsis thaliana by analyzing genetic and physiological responses to abiotic stressors across different regions.

Genomic signatures of host-specific selection in a parasitic plant

This study identifies genomic regions associated with host specificity in Striga hermonthica using whole genome sequencing and finds host-specific selection on haustorium development genes rather than strigolactone response.

CsMYB4a from Camellia sinensis Regulates the Auxin Signaling Pathway by Interacting with CsIAA4

This study identifies CsMYB4a as a multifunctional transcription factor that regulates the auxin signaling pathway and phenylpropane/lignin pathways in Camellia sinensis.

Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex

This study shows that Midkine suppresses AMPK activation by disrupting the LKB1-STRAD-Mo25 complex, promoting cancer cell proliferation and correlating with poor clinical outcomes in specific cancers.

Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2

This study reports the cryo-EM structure of PTH2R bound to TIP39 and a Gs protein, revealing ligand specificity and disease-associated mutation effects.

Improving localization precision via restricting biomolecule confined stochastic motion in SMLM

This study investigates stochastic motion of biomolecules in SMLM and shows that restricting this motion improves localization precision.

A multidrug resistant clinical P. aeruginosa isolate in the MLST550 clonal complex: uncoupled quorum sensing modulates the interplay of virulence and resistance

The paper identifies a multidrug-resistant P. aeruginosa strain with hyperactive quorum sensing that enhances virulence and resistance.

Isolation And Characterization Of Key Genes That Promote Flavonoid Accumulation In Purple-Leaf Tea (Camellia sinensis L.)

The paper identifies and characterizes two genes, CsMYB6A and CsUGT72AM1, that promote flavonoid accumulation in purple-leaf tea, with CsMYB6A activating structural genes and CsUGT72AM1 catalyzing flavonol glycosylation.

Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis

The paper identifies DA1 as a ubiquitin-activated peptidase in Arabidopsis that cleaves and destabilizes E3 ligases and growth regulatory proteins to limit cell proliferation during organ development.