Author

S. Geng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:mouse· 7 Research Focus:cell signaling & trafficking· 4 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 3

Frequent Co-Authors

X. Wang· 4 shared L. Li· 3 shared X. Zhou· 3 shared Y. Li· 3 shared G. Han· 2 shared H. Gu· 2 shared J. Li· 2 shared L. He· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersImmunology

X. Wang

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

An arms race between 5'ppp-RNA virus and its alternative recognition receptor MDA5 in RIG-I-lost teleost fish

S. Geng, X. Lv, W. Zheng, T. Xu

The paper examines the evolutionary arms race between 5'ppp-RNA virus and the MDA5 receptor in RIG-I-lost teleost fish, showing how MDA5 compensates for RIG-I loss and how the virus counteracts this through m6A methylation.

eLife · Sep 30, 2024Peer-reviewedImmunology

Monocytes reprogrammed by 4-PBA potently contribute to the resolution of inflammation and atherosclerosis

S. Geng, R. Lu, Y. Zhang, Y. Wu, L. Xie, B. A. Caldwell, K. Pradhan, Z. Yi, J. Hou, F. Xu, X. Chen, L. Li

This study shows that 4-PBA reprograms monocytes to resolve inflammation and atherosclerosis by altering adhesion and increasing anti-inflammatory markers.

bioRxiv · Oct 19, 2023Immunology

Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs

H. Lyu, G. Yuan, X. Liu, X. Wang, S. Geng, T. Xia, X. Zhou, Y. Li, X. Hu, Y. Shi

This study shows that sustained store-operated calcium entry (SOCE) and chromatin accessibility in iTregs lead to phenotypical instability, unlike tTregs.

bioRxiv · Jun 4, 2023Immunology

Design principles of Cdr2 node patterns in fission yeast cells

H. E. Opalko, S. Geng, A. R. Hall, D. Vavylonis, J. B. Moseley

The paper investigates how Cdr2 nodes form and position in fission yeast cells using experimental and modeling approaches, finding that tip inhibition and cortical anchoring are sufficient for node assembly without a nucleus.

bioRxiv · Apr 19, 2023Cell Biology

FoxP3-mediated blockage of ryanodine receptor 2 is the molecular basis for the contact-based suppression by regulatory T cells

X. Wang, S. Geng, J. Meng, N. Kang, X. Liu, Y. Xu, H. Lv, Y. Xu, X. Xu, X. Song, B. Zhang, X. Wang, N. Nuerbulati, Z. Zhang, D. Zhai, , Y. Shi

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

bioRxiv · May 2, 2022 · PreprintImmunology

Epigenomic and transcriptomic differences between low-grade and acute inflammation in LPS-induced murine immune cells

L. B. Naler, Y.-P. Hsieh, S. Geng, Z. Zhou, L. Li, C. Lu

This study compares epigenomic and transcriptomic changes in murine monocytes under low-grade and acute inflammation induced by LPS, identifying pathway-specific responses and epigenetic regulation differences.

bioRxiv · Mar 28, 2021 · PreprintImmunology

Sessile bacterium unlocks ability of surface motility through mutualistic interspecies interaction

M. Wang, S. Geng, B. Hu, Y. Nie, X.-L. Wu

This paper identifies a mutualistic interaction between non-motile Dietzia and dimorphic Glycocaulis bacteria that enables surface motility through biosurfactant-mediated mechanisms and nutrient exchange.

Environmental Microbiology Reports · Nov 29, 2020Peer-reviewedMicrobiology

Recombinant Fc-fusion vaccine of RBD induced protection against SARS-CoV-2 in non-human primate and mice

Y. Sun, G. Han, W. Wei, Z. Hu, S. Sun, L. He, Z. Zhao, H. Gu, T. Wang, X. Yang, S. Chen, Y. Deng, J. Li, J. Zhao, L. Li, , Y. Zhao

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

bioRxiv · Nov 29, 2020 · PreprintImmunology

Rapid adaptation of SARS-CoV-2 in BALB/c mice: Novel mouse model for vaccine efficacy

H. Gu, Q. Chen, G. Yang, L. He, H. Fan, Y.-q. Deng, Y. Wang, Y. Teng, Z. Zhao, Y. Cui, Y. Li, X.-F. Li, J. Li, N. Zhang, X. Yang, , Y. Zhou

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

bioRxiv · May 2, 2020 · PreprintMicrobiology