Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.
Y. Ma, P. Li, Y. Hu, T. Qiu, L. Wang, H. Lu, K. Lv, M. Xu, J. Zhuang, X. Liu, S. He, B. He, S. Liu, L. Liu, Y. Wang, , Y.-Q. Chen
The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.
bioRxiv · Jan 15, 2023 · PreprintMicrobiology