S. Ding

This study investigates whether mesalamine affects SARS-CoV-2 infection and disease severity in mice and human intestinal cells, finding no change in viral levels but reduced ACE2 expression.

This study investigates how temperature affects SARS-CoV-2 Spike protein affinity for ACE2, finding increased binding at low temperatures, which is mitigated by the N501Y mutation.

This study shows that NSP1 is essential for murine rotavirus replication, pathogenesis, and transmission in vivo, even though it is not required for replication in cell culture.

This study uses live imaging to show that neutralizing antibodies against SARS-CoV-2 need both Fab and Fc functions to effectively prevent and resolve infection in mice.

This study identifies new subunits of Toxoplasma gondii's mitochondrial complex III using complexome profiling, revealing their essential role in parasite survival and drug target potential.

This paper shows fungal hyaluronic acid interacts with host CD44 to recruit autophagy proteins to phagosomes, promoting fungal internalization via a Ca2+ -CaMKKβ-AMPK-ULK1 signaling pathway.

The paper examines sex differences in MAIT cell responses in COVID-19 patients, finding reduced circulating MAIT cells in females and a protective gene signature associated with female MAIT cells.

This paper describes a multitope protein-peptide vaccine candidate, UB-612, that is immunogenic and prevents lung infection in animal models, with ongoing clinical trials.

The paper identifies CH25H and its product 25HC as inhibitors of SARS-CoV-2 replication by blocking membrane fusion.

This study shows that IgM plays a major role in neutralizing SARS-CoV-2 in convalescent plasma, with its depletion causing the greatest loss of neutralizing activity.

The paper identifies JIB-04 as a broad-spectrum antiviral that inhibits SARS-CoV-2 replication and coronavirus pathogenesis in vitro and in vivo.

This study uses smFRET to observe real-time conformational dynamics of SARS-CoV-2 spikes on virus particles, revealing multiple states and mechanisms of neutralization by antibodies and convalescent plasma.

This paper develops an in vitro assay to evaluate nucleotide analogs against SARS-CoV-2 RdRp, showing varying incorporation efficiencies and chain termination effects.

This study evaluates humoral responses against SARS-CoV-2 Spike in 106 infected individuals, finding persistent RBD-specific IgG and declining neutralizing activity over time.

This study develops two neutralization assays for SARS-CoV-2 using VSV and a clinical isolate, showing high concordance between monoclonal, polyclonal antibodies, and ACE2-Fc in neutralizing activity.

This study identifies a conserved GxxxG motif in IFITM3 that drives oligomerization and antiviral activity by promoting membrane rigidity.

This study shows SARS-CoV-2 infects human intestinal enterocytes via TMPRSS2 and TMPRSS4, but viral particles in stool are inactivated, suggesting limited fecal-oral transmission.

This study shows that iso-PhABA improves grape color and anthocyanin content more than ABA by enhancing enzyme activity and receptor affinity.

This study shows that loss of COX4i1 causes combined respiratory chain deficiency and impaired mitochondrial proteosynthesis by disrupting cI and cIV biogenesis.

The paper shows that stress-induced myonectin improves glucose homeostasis by inhibiting glycemic response to epinephrine and enhancing insulin sensitivity in adipose tissues.

This study evaluates the effects of Lactobacillus plantarum 15-1 and fructooligosaccharide on broiler chickens challenged with E. coli O78, showing improved intestinal morphology, reduced intestinal injury, and enhanced immune responses.

This paper develops a novel Hmox1 reporter mouse to measure physiological responses to stressors, showing it accurately reflects oxidative and inflammatory stimuli.