S. Singh

SYS-Mut identifies functional significance of rare somatic mutations in cancer by integrating multi-omic data, revealing lipidogenic networks as therapeutic targets in HNSC.

This study identifies dynamic phenotypic states in oral cancer cells and their association with poor prognosis through transcriptomic heterogeneity and drug tolerance.

The paper was withdrawn due to concerns about the integrity of the reported results on alternative splicing of U2AF2.

This study identifies GRAMD1C as a negative regulator of starvation-induced autophagy and mitochondrial function through cholesterol transport between the ER and mitochondria.

This study shows that IL-6 signaling is required for chemotaxis of mature dendritic cells by facilitating CCR7 internalization and recycling.

This study shows Telmisartan reduces Chikungunya virus infection in vitro and in vivo by modulating host pathways including AT1/PPAR-γ/MAPKs.

The paper studies microbial community dynamics in granular, biofilm, and planktonic methanogenic microbiomes treating LCFA-rich wastewater, finding spatial compartmentalization and environmental drivers shaping community assembly.

This study identifies novel SARS-CoV-2 epitopes using mass spectrometry and validates their immunogenicity by T cell recognition.

This study shows that in silico predicted SARS-CoV-2 epitopes do not reliably elicit T cell responses against naturally presented epitopes.

This study shows YAP1 is essential for bile duct development and reveals hepatocyte adaptation in its absence.

This study identifies the EphB2-MYC axis as a key driver of Barrett's Esophagus progression to esophageal adenocarcinoma and a potential therapeutic target.

This study evaluates the replication, antibody sensitivity, and vaccine efficacy of the SARS-CoV-2 B.1.617.2 Delta variant compared to other variants and vaccine-elicited immunity.

This paper develops a 3-D vascularized breast cancer model to study osteoblast influence on tumor progression and identifies gene expression changes associated with pre-metastatic niche formation.

This study evaluates the efficacy of three herbicides against Rumex spp. in wheat, finding that carfentrazone + metsulfuron provides 70-90% control at double the recommended dose.

The paper identifies nine promoter-variant strains of HIV-1C in Indian patients, showing genetic diversity in transcription factor binding sites that may affect viral latency and reservoir characteristics.

The paper investigates how a cryptic pocket in β-lactamase, formed under the Ω-loop, enhances enzyme activity against penicillin, suggesting excited states can improve function.

This study identifies molecular interfaces that mediate EphA2 receptor assembly and distinguishes between canonical and noncanonical signaling pathways.

The paper analyzes monoclonal antibodies from vaccinated non-human primates to identify a conserved immunodominant epitope in HIV-1 Env and how different lineages target it for potent neutralization.

The paper examines the antibody response to SARS-CoV-2 mRNA vaccines in pregnant women and their neonates, highlighting the need for further study on vaccine immunology during pregnancy.

This paper shows that combining MEK and STAT3 inhibitors reprograms stromal inflammation and enhances immunotherapy response in pancreatic cancer.

The paper investigates how loss of GGTA1 function in primates affects host-microbiota interactions, finding that it reduces microbiota pathogenicity through IgA targeting of Gal-expressing bacteria.

The paper identifies recurrent transcriptional regulatory heterogeneities in early-stage luminal breast cancer using stochastic profiling and 10-cell RNA sequencing, revealing genes associated with EMT and pan-cancer drivers.

This study identifies regulatory state heterogeneity in small-cell lung cancer cells in vitro and in vivo, showing increased fragmentation in the liver and its prognostic relevance in human tumors.

This study identifies replication stress in premalignant OPCs before glioma formation using stochastic profiling in a mouse model.

This study identifies single domain antibodies that neutralize SARS-CoV2 by targeting the cleavage site and receptor binding domain of the spike protein, showing their stability and effectiveness in blocking infectivity.

This paper identifies mucoricin, a ricin-like toxin produced by Mucorales fungi, critical for mucormycosis pathogenesis and a potential therapeutic target.

This study repositions Alisporivir, an anti-Hepatitis C drug, as a potential treatment for artemisinin-resistant malaria by targeting PfCyP-19B, which is overexpressed in resistant parasites.

This study identifies metabolic reprogramming in ibrutinib-resistant DLBCL using multi-omics integration, revealing the BTK-PI3K-AKT-IL4I1 axis as a key driver of drug resistance.

This study evaluates the antimalarial effect of Prasugrel, an FDA-approved purinergic receptor antagonist, on Plasmodium falciparum by targeting PfSR12, a putative purinergic receptor.