S. Singh

This study examines nAb responses in an infant with interclade HIV-1 superinfection, finding that neutralizing antibodies primarily target the superinfecting strain and depend on glycans.

This paper investigates how Nsp10 activates Nsp16 and identifies a cryptic pocket in SARS-CoV-2 Nsp16 that could be targeted for pan-coronavirus antivirals.

This study shows that HIV-1 broadly neutralizing antibodies and plasma from HIV-1 infected children can cross-neutralize SARS-CoV-2 by targeting conserved epitopes and glycans on the spike protein.

The paper identifies a NOTCH-YAP1/TEAD-DNMT1 axis that drives hepatocyte reprogramming into intrahepatic cholangiocarcinoma and reveals its role in tumor development.

This study identifies a single sulfatase essential for colonic mucin O-glycan metabolism and intestinal colonization by Bacteroides thetaiotaomicron.

This study evaluates the protective efficacy of a CRISPR-edited Leishmania major strain against visceral leishmaniasis in hamsters and shows it induces a pro-inflammatory immune response and prevents disease.

This study shows the bone microenvironment enhances metastatic potential of cancer cells, enabling further dissemination and multi-organ metastasis, independent of genetic selection.

The paper shows that the bone microenvironment induces endocrine resistance in ER+ breast cancer metastases through epigenomic reprogramming mediated by EZH2.

This study identifies GAK and PRKCD as positive regulators of PRKN-independent mitophagy through genetic screening and functional analysis in vitro and in vivo.

This study establishes a mouse model to investigate PPRV pathogenesis, showing that IFNR KO mice succumb to infection regardless of dose, with neutrophils/macrophages transporting virus to CNS and CD8+ T cells providing protection.

This study identifies PfAP2-G2 as a critical transcription factor for Plasmodium falciparum gametocyte maturation, showing it regulates gene expression and interacts with chromatin remodeling proteins.

This study identifies orf19.2500 as a mitochondrial protein essential for biofilm growth, virulence, and drug resistance in Candida albicans, with unique evolutionary inserts.

This study shows that HER2/HER3 signaling and FOXA1 deacetylation drive ER-independent growth in hormone-resistant breast tumors by altering FOXA1 chromatin binding and function.

This study identifies a glycoside derivative, Gly 2, with potent antileishmanial activity against Leishmania donovani, targeting the metalloprotease Gp63 and showing efficacy against both visceral leishmaniasis and post-kala-azar dermal leishmaniasis.

This paper designs and validates Multi-Patch Vaccines against SARS-CoV-2 using a reverse epitomics approach, showing potential to cover a large ethnically diverse human population.

This paper demonstrates that vanadium pentoxide nanosheets act as antioxidant nanozymes to counteract HIV-1 by modulating redox potential and inhibiting viral reactivation and Mtb proliferation.

The paper analyzes SARS-CoV-2 genomic data from India to trace introduction and local transmission, identifying multiple clades and highlighting the need for molecular surveillance.

This study shows that Plasmodium falciparum pore-forming proteins (PLPs) induce barrier cell dysfunction through necrotic cell death, contributing to severe malaria pathogenesis.

This study develops an intranasal vaccine that induces systemic and mucosal immunity against SARS-CoV-2 in mice, with single-cell RNA-sequencing confirming T and B cell responses in nasal-associated lymphoid tissues.

This study evaluates the anti-Bacillus anthracis activity of common plants, finding that garlic extract shows potent bactericidal effects and stability under various conditions.

This study isolates and characterizes bacterial endophytes from Salicornia brachiata, identifying bioactive compounds with antimicrobial potential.

The paper was withdrawn due to concerns about the validity of the reported splicing mechanism and data integrity.

This study shows that the rice plastidial phosphorylase Pho1 has a dual role in both source and sink processes through its interaction with photosystem I and effects on CO2 assimilation.

This study shows KDM6B promotes oncogenic CDK4/6-pRB-E2F pathway activation in neuroblastoma by maintaining enhancer activity, and its inhibition correlates with poor patient survival.

This study shows DHA improves steroid sensitivity in asthma models and is lower in steroid-insensitive asthmatics.

The paper uses exascale simulations to study SARS-CoV-2 protein dynamics, revealing cryptic epitopes and conformational changes that inform antiviral target design.

This study investigates the SARS-CoV-2 nucleocapsid protein's dynamics, disorder, and RNA phase separation using single-molecule spectroscopy and simulations, revealing its multivalent RNA binding properties and phase separation behavior.

The paper identifies a monoclonal antibody, PI3-E12, that neutralizes HPIV3 and provides protection in cotton rats, showing potential for clinical use in both immunocompetent and immunocompromised individuals.

The paper analyzes the genotypic and antigenic characteristics of an Indian SARS-CoV-2 isolate, identifying its strain and predicting B and T cell epitopes for vaccine design.