Q. Long

Calorie Restriction Induces Degeneration of Neurons with Mitochondrial DNA Depletion by Altering ER-Mitochondria Calcium Transfer

This study shows that calorie restriction exacerbates neuronal degeneration in mtDNA-depleted neurons by increasing ER-mitochondria calcium transfer, suggesting CR may not be beneficial for mitochondrial epilepsy.

OsAAI1-OsMADS25 module orchestrates root morphogenesis by fine-tuning IAA in drought stressed rice

This study shows that OsAAI1 and OsMADS25 regulate rice root growth and drought resistance by modulating IAA levels and downstream gene expression.

The genomic and epigenomic dynamics of hemizygous genes across crops with contrasting mating systems

This study examines hemizygous genes in 22 crop genomes, finding higher hemizygosity in clonal lineages and distinct expression and epigenetic features compared to diploid genes.

Deep learning based genomic breeding of pest-resistant grapevine

This study uses deep learning and genome-wide association studies to identify pest-resistant genes in grapevine, achieving high accuracy in predicting pest damage.

Prokaryotic microbial diversity analysis and metabolic function prediction of salt lakes on the Qinghai-Tibet Plateau

This study analyzes microbial diversity and metabolic functions in two salt lakes on the Qinghai-Tibet Plateau using metagenomics, revealing differences in microbial composition and salinity adaptation strategies.

Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors

This study shows Mecp2 negatively regulates quiescence exit by activating metabolic genes and repressing proliferation genes, with nuclear receptors Rara and Nr1h3 playing a key role.

Senescent cells develop PDK4-dependent hypercatabolism and form an acidic microenvironment to drive cancer resistance

This study identifies PDK4-dependent hypercatabolism in senescent cells that creates an acidic microenvironment, promoting cancer resistance and age-related pathologies.

Tumor subclones, where are you?

This study compares bulk and single-cell mutational analysis to assess tumor clonal structure, finding that bulk analysis underestimates subclonal complexity and dynamic evolution.

In-depth investigation of microRNA-mediated cross-kingdom regulation between Asian honey bee and microsporidian

This study investigates microRNA-mediated cross-kingdom regulation between Asian honey bee and microsporidian using RNA-seq and small RNA-seq data, identifying miRNA-target mRNA interactions and their roles in glycolysis, virulence, and immune response.

CircRNA-regulated immune response of Asian honey bee workers to microsporidian infection

This study identifies circRNAs in Asian honey bee midguts infected with Nosema ceranae and shows their role in regulating immune responses through miRNA targeting and pathway involvement.

Characterization of SARS-CoV-2 variants B.1.617.1 (Kappa), B.1.617.2 (Delta) and B.1.618 on cell entry, host range, and sensitivity to convalescent plasma and ACE2 decoy receptor

This study characterizes SARS-CoV-2 variants Kappa, Delta, and B.1.618, finding increased ACE2 binding in non-human hosts, enhanced spike cleavage, and reduced neutralization sensitivity, but maintained sensitivity to ACE2 decoy receptor.

Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption

This study identifies the Y453F mutation in SARS-CoV-2 spike protein as enhancing binding to mink ACE2 while maintaining human ACE2 utilization, highlighting its role in host adaptation.

KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype

This study shows KDM4 promotes epigenomic changes in senescent cells, enhances the SASP, and presents a therapeutic target for age-related diseases.

Endoplasmic Reticulum Associated Degradation (ERAD) Deficiency Promotes Mitochondrial Dysfunction and Transcriptional Rewiring in Human Hepatic Cells

This study shows that ERAD deficiency causes mitochondrial dysfunction and transcriptional changes in human hepatic cells, linking ERAD to mitochondrial health.

Senescent stromal cells promote cancer resistance through SIRT1 loss-potentiated overproduction of small extracellular vesicles

This study shows senescent stromal cells release sEVs that promote cancer drug resistance via SIRT1 loss, and suggests targeting SIRT1 could prevent this resistance.

O-GlcNAcylation of SAMHD1 Indicating a Link between Metabolic Reprogramming and Anti-HBV Immunity

This study shows that HBV infection enhances the hexosamine biosynthesis pathway, leading to O-GlcNAcylation of SAMHD1, which boosts antiviral immunity against HBV and HIV-1.

Single-cell dissection of a rare human prostate basal cell carcinoma

This study characterizes the mutational and transcriptomic landscapes of a rare prostate basal cell carcinoma using single-cell sequencing, revealing unique gene expression and regulatory patterns.

Overexpressing CsGH3.1 and CsGH3.1L reduces susceptibility to Xanthomonas citri subsp. citri by repressing auxin signaling in citrus (Citrus sinensis Osbeck)

This study shows overexpressing CsGH3.1 and CsGH3.1L in citrus reduces susceptibility to Xcc by repressing auxin signaling and enhancing defense responses.

Patterns of polymorphism at the self-incompatibility locus in 1,083 Arabidopsis thaliana genomes

The paper analyzes polymorphism at the S-locus in 1,083 Arabidopsis thaliana genomes to understand the historical loss of self-incompatibility, finding multiple independent origins and recombination events during post-glacial colonization.