N. Yu

Brain transcriptomics reveals features of the host response after dengue virus type I infection induced central nervous system injury in AGB6 mice

This study uses brain transcriptomics to identify host response features in AGB6 mice infected with dengue virus type I, revealing cytokine-cytokine receptor interaction as a key pathway in neurological damage.

Target-aware Molecule Generation for Drug Design Using a Chemical Language Model

This paper introduces TamGen, a chemical language model for target-aware molecule generation, and shows it produces high-quality compounds with inhibitory activity against Tuberculosis ClpP protease.

Quantitative Learning of Cellular Features From Single-cell Transcriptomics Data Facilitates Effective Drug Repurposing

This study introduces SuperFeat, a framework that uses single-cell transcriptomics data to identify drug targets by modeling adverse cellular states, validated in vitro and in vivo.

Convergent evolution of noxious heat sensing by TRPA5, a novel class of heat sensor in Rhodnius prolixus

The paper identifies TRPA5 as a novel heat-sensing receptor in Rhodnius prolixus, showing high thermosensitivity and structural similarities to fruit fly TRPA1.

A novel biopolymer for mucosal adjuvant against respiratory pathogens

This study evaluates a novel biopolymer, GC, as a nasal mucosal adjuvant for respiratory vaccines, showing improved immune response and survival in mice compared to Addavax.

Acute noise causes down-regulation of ECM protein expression in guinea pig cochlea

This study uses proteomics to identify down-regulated ECM proteins in guinea pig cochleae after noise exposure, linking them to hearing loss mechanisms.

Single-cell RNA-seq of the stromal vascular fraction of adipose tissue reveals lineage-specific changes in cancer-related lymphedema

This study uses single-cell RNA-seq to analyze stromal vascular fraction cells in cancer-related lymphedema, identifying lineage-specific changes and potential therapeutic targets.

Neonicotinoids stimulate H2-limited methane emission in Periplaneta americana through the regulation of gut bacterium community

This study shows neonicotinoids increase methane emission in Periplaneta americana by altering gut bacteria to produce more hydrogen, which methanogens use to generate methane.

Single-cell RNA-seq reveals lineage-specific regulatory changes of fibroblasts and vascular endothelial cells in keloid

This study uses single-cell RNA-seq to analyze keloid tissue and identifies lineage-specific regulatory changes in fibroblasts and vascular endothelial cells, highlighting key pathways and potential therapeutic targets.

The evolution of red colour vision is linked to coordinated rhodopsin tuning in lycaenid butterflies

This study links the evolution of red colour vision in lycaenid butterflies to coordinated rhodopsin tuning, showing how molecular changes in multiple opsins expand spectral sensitivity for visual tasks.

Anethole dithiolethione improves liver fatty acid metabolism in hamster fed high-fat diets

This study shows that anethole dithiolethione improves liver fatty acid metabolism in hamsters on high-fat diets by altering fatty acid profiles and regulating key metabolic pathways.

Effects of the anesthetic MS-222 on silver pomfret (Pampus argenteus) juveniles under aquaculture treatment stresses

This paper determines the optimal dose and duration of MS-222 anesthesia for silver pomfret juveniles under aquaculture stress and shows it reduces oxidative damage and stress response.