A. Singh

The paper investigates sex-specific genetic effects on fitness in Drosophila melanogaster using three approaches across two mating environments, finding concordant genetic variation effects and stronger selection against certain mutations in females.

This study shows that Rab5 and EEA1 form a two-component molecular motor using GTP hydrolysis to drive cyclic flexibility transitions that perform mechanical work.

This study uses a tissue-engineered human dermal microvessel model to investigate Borrelia burgdorferi invasion and intravasation, finding no adhesin-mediated interactions and showing Bb-induced endothelium activation.

This study shows that Drosophila melanogaster populations selected for increased post-infection survival show reduced mating-induced immune suppression compared to control populations.

This study identifies a proton-activated Deg/ENaC channel in Trichoplax adhaerens, showing it evolved independently from mammalian ASIC channels.

This study shows that Drosophila melanogaster can rapidly evolve increased resistance to E. faecalis infection without life-history costs or abiotic stress resistance.

This study identifies temperature-sensitive contacts in disordered loops of Enzyme I homologs that tune catalytic activity across temperatures.

The paper analyzes the timing of protein threshold-crossing in growing cells using first passage time statistics and compares different models of gene expression.

This study shows that YAP/TAZ signaling is involved in TGFβ2-induced dysfunction of Schlemm's canal cells and that inhibiting YAP/TAZ can reduce this dysfunction.

The paper introduces improved methods for bulk cultivation and fixation of Loxodes ciliates, enabling better preservation for fluorescence microscopy.

This paper identifies a new class of TEAD-YAP inhibitors with a novel binding mode that suppresses transcriptional activity and shows anti-proliferative effects in cancer cells.

This paper describes a citizen science computer game that teaches and contributes to genomic data analysis through a story mode and instructor tools.

This paper identifies a NOTCH1-SIRT1-KAT7 axis in T-ALL that promotes leukemia and resistance to therapy, suggesting new therapeutic targets.

MaLAdapt identifies novel adaptive introgression loci from Neanderthals and Denisovans in non-African populations using machine learning.

This study shows female Drosophila melanogaster contribute to the binding of the seminal Sex Peptide to sperm, beyond male-derived factors.

This study examines how resource limitation through starvation and sexual activity affects host survival and pathogen growth in Drosophila infected with bacterial pathogens, finding pathogen-specific outcomes.

The paper defines newly synthesized proteins as HSR activators and shows Sis1 induction enhances fitness during stress without providing negative feedback to the HSR.

This study identifies moxifloxacin-induced oxidative stress in Mycobacterium tuberculosis as a mechanism of killing, showing that reductive stress and iron contribute to ROS accumulation and drug efficacy.

This study shows dietary αKG inhibits SARS-CoV-2 infection and reduces lung inflammation and thrombosis in animals, restoring oxygen saturation.

The paper analyzes sequestration-based feedback mechanisms in biological systems, showing how degradation enhances robustness to disturbances and how stochastic fluctuations are influenced by feedback strength.

This study uses single B-cell cloning to identify a high-affinity SARS-CoV-2 neutralizing antibody, SAR03, from patient blood samples.

This study shows that Drosophila melanogaster adapted to bacterial infections maintain better immune function under poor diets, with sex-dependent effects.

This study evaluates Bi121's antiviral activity against multiple SARS-CoV-2 variants using pseudotyped viruses and cell-based assays, showing broad-spectrum efficacy.

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

This study examines how chronic hyperglycemia affects macrophage effector functions in pulmonary tuberculosis, finding reduced phagocytic capacity and altered PRR expression in diabetic TB patients.

This study develops a 3D hydrogel system to mimic the in vivo mouse optic nerve head astrocyte microenvironment and assesses their reactivity to TGFβ2 treatment.

This paper introduces a computational method to estimate state-switching rates in isogenic cell populations using Luria-Delbruck fluctuation test data and benchmarks it with simulated data.

The paper develops a continental-scale tree species classifier using NEON data, showing better accuracy than site-specific models and highlighting challenges in species classification across diverse ecosystems.

The paper shows cancer reactivates embryonic splicing events, linking development and cancer through splicing factors and identifies potential therapeutic targets.