A. Singh

This study determines the optimal harvesting strategy for ecological populations by analyzing stochastic logistic models and comparing threshold-based strategies to constant-rate harvesting.

This study shows that PERK inhibition reduces SLC7A11 expression and sensitizes colon cancer cells to ferroptosis, suggesting PERK inhibitors as potential therapeutics.

This study identifies ACLY as an overexpressed therapeutic target in T-ALL, showing its antileukemic effects and reciprocal relationship with MYC.

This paper develops a prodrug strategy to overcome phenotypic AMR in Mtb by enhancing drug permeability and targeting hypoxic persisters.

This study shows gene flow from wild relatives reduced genetic load in domesticated grain amaranth and created reproductive barriers between crop species.

This study shows that Mtb methyltransferase Rv2067c modifies host histone H3K79 methylation, inhibiting apoptosis and enhancing necrosis to promote bacterial survival.

The paper analyzes stochastic population dynamics under environmental perturbations, showing that rare events with high death probability increase extinction risk and deriving an optimal harvesting rate for maximum yield.

The paper maps the phenotypical effects of TP53 missense mutations across cancer types and tissues, identifying potential therapeutic targets.

This study uses FCS to measure oligonucleotide dynamics in phase-separated droplets, showing spatial restriction significantly impacts diffusion.

The paper maps plant trait variability across different spatial resolutions in the Western Ghats using imaging spectroscopy and identifies environmental drivers of trait variation.

This study identifies Rv1636 as an essential cAMP-binding protein in Mycobacterium tuberculosis that regulates intracellular cAMP levels and is required for bacterial survival.

This study shows that TFII-I is essential for maintaining innate B cell properties, with its loss causing myeloid-like transcriptomic changes and increased IgG3 switching.

This study compares IgG subclass responses to RBC transfusion and alum vaccination, showing differential regulation by STAT6.

This study investigates the molecular factors controlling viscoelasticity and flow activation energy in biomolecular condensates using engineered polypeptides and DNA.

The paper derives the exact distribution of quantal content in synaptic transmission for different AP input patterns and validates it with electrophysiological data from mice.

This study identifies imaging and spatial biomarkers in glioblastoma that correlate with molecular features and oncogenic drivers using machine learning on MRI data.

The paper inhibits early-acting autophagy genes in C. elegans neurons, finding that it reduces protein aggregates, increases exopher production, and extends lifespan, with ATG-16.2's WD40 domain being critical for these effects.

The paper develops a multi-temporal hierarchical model to improve rare tree species classification in airborne imagery, achieving 75% accuracy for 14 species and generating species maps for over 670,000 trees.

SCIPDb is a database that compiles phenome and transcriptome data on plant responses to combined stresses, identifying novel genes and pathways involved in stress tolerance.

This study uses live-cell imaging and mathematical modeling to analyze Tax expression dynamics in HTLV-1 infected T-cells, revealing heterogeneous patterns and impacts on cell behavior.

This paper develops an in silico model of trabecular bone remodeling in aging mice, showing how changes in OPG, RANKL, and Scl levels affect bone volume fraction.

This study identifies seven small molecules that inhibit Chikungunya virus replication by targeting the G3BP1 protein's FGDF binding pocket.

This study identifies endogenous protein pyrophosphorylation in human cell lines using a tailored pyrophosphoproteomics workflow, revealing its role in rDNA transcription regulation.

This study identifies ciTRAN, a circular RNA induced by HIV-1 Vpr that sequesters SRSF1 to enhance viral transcription.

The paper analyzes cell growth dynamics in Arabidopsis leaves to show that coordinated growth across the leaf blade is necessary for maintaining flatness, and that the jaw-D mutant disrupts this coordination.

This study shows that simvastatin reduces YAP/TAZ activity and ECM dysfunction in glucocorticoid-treated human trabecular meshwork cells.

The paper revises the genus Xanthomonas and proposes a new family Frateuriaceae based on deep phylo-taxonogenomic analysis of the order Xanthomonadales.

This study identifies two brain atrophy dimensions in Alzheimer's disease using Surreal-GAN and links them to genetic and clinical factors, revealing distinct pathological mechanisms.

This study identifies platelet phosphatidylserine as a critical mediator of thrombosis in heparin-induced thrombocytopenia and shows that blocking it prevents thrombus formation.