Author

J. Zang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Bioengineering· 1 Cancer Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

C. Zhang· 3 shared D. LAVILLETTE· 3 shared S. Xu· 3 shared Z. Huang· 3 shared X. Zhang· 2 shared Y. Yang· 2 shared Y. Zhang· 2 shared B. Ouyang· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersMicrobiology

C. Zhang

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Dual Ethanolamine Head Groups in Ionizable Lipids Facilitate Phospholipid-free Stable Nanoparticle Formulation for Augmented and Safer mRNA Delivery

J. Lu, T. Jiang, X. Li, S. Tan, Y. Zhang, H. Gu, L. Chen, J. Guo, R. Yu, J. Zang, D. Ouyang, H. Yu, H. Yao, M. Qiu, J. Lin

This paper introduces ionizable lipids with dual ethanolamine head groups for phospholipid-free mRNA delivery, showing improved stability, efficiency, and reduced toxicity.

bioRxiv · Oct 13, 2023 · PreprintBioengineering

The microtubule-associated protein SlMAP70 interacts with SlIQD21 and regulates fruit shape formation in tomato

Z. Bao, Y. Guo, Y. Deng, J. Zang, J. Zhang, B. Ouyang, X. Qu, K. Burstenbinder, P. Wang

This study identifies SlMAP70 as a regulator of tomato fruit shape by interacting with SlIQD21 and modulating microtubule organization during fruit development.

bioRxiv · Aug 8, 2022 · PreprintPlant Biology

An mRNA vaccine candidate for the SARS-CoV-2 Omicron variant

J. Zang, C. Zhang, Y. Yin, S. Xu, W. Qiao, D. LAVILLETTE, H. Wang, Z. Huang

This paper develops an mRNA vaccine targeting the Omicron variant's RBD, showing it induces Omicron-specific neutralizing antibodies but not against wildtype or Delta strains.

bioRxiv · Feb 7, 2022 · PreprintMicrobiology

Structural insights into the recognition of histone H3Q5 serotonylation by WDR5

J. Zhao, W. Chen, Y. Zhang, F. Yang, N. Shen, X. Zhang, X. Mo, J. Zang

This study identifies WDR5 as a reader of H3Q5ser, showing it binds to this modification and promotes transcription in neuroblastoma cells, suggesting a role in tumorigenesis.

Science Advances · Jun 18, 2021Peer-reviewedBiochemistry

Efficacy of ancestral receptor-binding domain, S1 and trimeric spike protein vaccines against SARS-CoV-2 variants B.1.1.7, B.1.351, and B.1.617.1

Y. Yang, J. Zang, S. Xu, X. Zhang, S. Yuan, D. Lavillette, C. Zhang, Z. Huang

This study compares the efficacy of ancestral RBD, S1, and S-trimer vaccines against SARS-CoV-2 variants B.1.1.7, B.1.351, and B.1.617.1, finding that RBD and S-trimer induce higher neutralizing titers and maintain effectiveness against variants.

bioRxiv · Jun 2, 2021 · PreprintImmunology

A comprehensive map of genetic interactions in childhood cancer reveals multiple underlying biological mechanisms

J. T. Daub, S. Amini, D. J. E. Kersjes, X. Ma, N. Jäger, J. Zang, S. M. Pfister, F. C. P. Holstege, P. Kemmeren

The paper identifies genetic interactions in childhood cancers using a statistical pipeline, revealing 15 co-occurring and 27 mutually exclusive gene pairs, with most mechanisms linked to tumor subtypes or pathways.

bioRxiv · Nov 17, 2020Cancer Biology

Zinc dysregulation in slc30a8 (znt8) mutant zebrafish leads to blindness and disrupts bone mineralisation

E. W. Mackay, S. Ibanez Molero, L. Harjani Tirathdas, J. Peterson-Maduro, J. Zang, S. C. Neuhauss, S. Schulte-Merker, S. W. Wilson

This study shows that slc30a8 mutants in zebrafish develop blindness and bone mineral defects due to zinc accumulation in non-pigmented tissues, suggesting a role for pigment cells in zinc homeostasis.

bioRxiv · Sep 2, 2020 · PreprintPhysiology

Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement

J. Zang, C. Gu, B. Zhou, C. Zhang, Y. Yang, S. Xu, X. Zhang, Y. Zhou, L. Bai, Y. Wu, Z. Sun, R. Zhang, Q. Deng, Z. Yuan, H. Tang, , Z. Huang

This study shows that immunization with SARS-CoV-2 RBD induces antibodies that neutralize both SARS-CoV-2 and SARS-CoV without causing antibody-dependent enhancement.

bioRxiv · May 21, 2020Microbiology